Brain-derived neurotrophic factor and mental disorders

Chin Chuen Lin; Tiao Lai Huang

doi:10.1016/j.bj.2020.01.001

Brain-derived neurotrophic factor and mental disorders

Chin Chuen Lin, Tiao Lai Huang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

113 Scopus citations

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.

Original language	English
Pages (from-to)	134-142
Number of pages	9
Journal	Biomedical Journal
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/j.bj.2020.01.001
State	Published - 04 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Chang Gung University

Keywords

Bipolar disorder
Brain-derived neurotrophic factor
Epigenetics
Major depressive disorder
Proteomics
Schizophrenia

Access to Document

10.1016/j.bj.2020.01.001

Cite this

@article{79ab9529cb3842119dbc1899350c504c,

title = "Brain-derived neurotrophic factor and mental disorders",

abstract = "Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.",

keywords = "Bipolar disorder, Brain-derived neurotrophic factor, Epigenetics, Major depressive disorder, Proteomics, Schizophrenia",

author = "Lin, {Chin Chuen} and Huang, {Tiao Lai}",

note = "Publisher Copyright: {\textcopyright} 2020 Chang Gung University",

year = "2020",

month = apr,

doi = "10.1016/j.bj.2020.01.001",

language = "英语",

volume = "43",

pages = "134--142",

journal = "Biomedical Journal",

issn = "2319-4170",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Brain-derived neurotrophic factor and mental disorders

AU - Lin, Chin Chuen

AU - Huang, Tiao Lai

PY - 2020/4

Y1 - 2020/4

N2 - Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.

AB - Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.

KW - Bipolar disorder

KW - Brain-derived neurotrophic factor

KW - Epigenetics

KW - Major depressive disorder

KW - Proteomics

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85084154344&partnerID=8YFLogxK

U2 - 10.1016/j.bj.2020.01.001

DO - 10.1016/j.bj.2020.01.001

M3 - 文献综述

C2 - 32386841

AN - SCOPUS:85084154344

SN - 2319-4170

VL - 43

SP - 134

EP - 142

JO - Biomedical Journal

JF - Biomedical Journal

IS - 2

ER -

Brain-derived neurotrophic factor and mental disorders

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this