Brain protection by methylprednisolone in rats with spinal cord injury

Chia Mao Chang; Ming Hsueh Lee; Ting Chung Wang; Hsu Huei Weng; Chiu Yen Chung; Jen Tsung Yang

doi:10.1097/WNR.0b013e32832d0a28

Brain protection by methylprednisolone in rats with spinal cord injury

Chia Mao Chang, Ming Hsueh Lee, Ting Chung Wang, Hsu Huei Weng, Chiu Yen Chung, Jen Tsung Yang^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

23 Scopus citations

Abstract

Traumatic spinal cord injury is clinically treated by high doses of methylprednisolone. However, the effect of methylprednisolone on the brain in spinal cord injury patients has been little investigated. This experimental study examined Bcl-2 and Bax protein expression and Nissl staining to evaluate an apoptosis-related intracellular signaling event and final neuron death, respectively. Spinal cord injury produced a significant apoptotic change and cell death not only in the spinal cord but also in the supraventricular cortex and hippocampal cornu ammonis 1 region in the rat brains. The treatment of methylprednisolone increased the Bcl-2/Bax ratio and prevented neuron death for 1-7 days after spinal cord injury. These findings suggest that rats with spinal cord injury show ascending brain injury that could be restricted through methylprednisolone management.

Original language	English
Pages (from-to)	968-972
Number of pages	5
Journal	NeuroReport
Volume	20
Issue number	10
DOIs	https://doi.org/10.1097/WNR.0b013e32832d0a28
State	Published - 01 07 2009

Keywords

Apoptosis
Ascending brain injury
Methylprednisolone
Spinal cord injury

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10.1097/WNR.0b013e32832d0a28

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abstract = "Traumatic spinal cord injury is clinically treated by high doses of methylprednisolone. However, the effect of methylprednisolone on the brain in spinal cord injury patients has been little investigated. This experimental study examined Bcl-2 and Bax protein expression and Nissl staining to evaluate an apoptosis-related intracellular signaling event and final neuron death, respectively. Spinal cord injury produced a significant apoptotic change and cell death not only in the spinal cord but also in the supraventricular cortex and hippocampal cornu ammonis 1 region in the rat brains. The treatment of methylprednisolone increased the Bcl-2/Bax ratio and prevented neuron death for 1-7 days after spinal cord injury. These findings suggest that rats with spinal cord injury show ascending brain injury that could be restricted through methylprednisolone management.",

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AU - Chung, Chiu Yen

AU - Yang, Jen Tsung

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AB - Traumatic spinal cord injury is clinically treated by high doses of methylprednisolone. However, the effect of methylprednisolone on the brain in spinal cord injury patients has been little investigated. This experimental study examined Bcl-2 and Bax protein expression and Nissl staining to evaluate an apoptosis-related intracellular signaling event and final neuron death, respectively. Spinal cord injury produced a significant apoptotic change and cell death not only in the spinal cord but also in the supraventricular cortex and hippocampal cornu ammonis 1 region in the rat brains. The treatment of methylprednisolone increased the Bcl-2/Bax ratio and prevented neuron death for 1-7 days after spinal cord injury. These findings suggest that rats with spinal cord injury show ascending brain injury that could be restricted through methylprednisolone management.

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Brain protection by methylprednisolone in rats with spinal cord injury

Abstract

Keywords

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