Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae)

Ping Jyun Sung; Yu Pei Chen; Tsong Long Hwang; Wan Ping Hu; Lee Shing Fang; Yang Chang Wu; Jan Jung Li; Jyh Horng Sheu

doi:10.1016/j.tet.2006.03.086

Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae)

Ping Jyun Sung^*
, Yu Pei Chen
, Tsong Long Hwang
, Wan Ping Hu
, Lee Shing Fang
, Yang Chang Wu
, Jan Jung Li
, Jyh Horng Sheu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

29 Scopus citations

Abstract

Four new briarane-related diterpenoids, designated as briaexcavatins C-F (1-4), were isolated from the Formosan octocoral Briareum excavatum, collected off southern Taiwan coast. The structures of these new metabolites were elucidated by the interpretation of spectroscopic and chemical methods. The configuration of 1 was further supported by molecular mechanics calculations. Briarane 1 has been shown to exhibit mild cytotoxicity toward MDA-MB-231 human breast tumor cells and briarane 3 was found to show activity to inhibit neutrophil elastase release in humans.

Original language	English
Pages (from-to)	5686-5691
Number of pages	6
Journal	Tetrahedron
Volume	62
Issue number	24
DOIs	https://doi.org/10.1016/j.tet.2006.03.086
State	Published - 12 06 2006

Keywords

Briaexcavatin
Briarane
Briareum excavatum
Cytotoxicity
Human neutrophil elastase
Octocoral

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tet.2006.03.086

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title = "Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae)",

abstract = "Four new briarane-related diterpenoids, designated as briaexcavatins C-F (1-4), were isolated from the Formosan octocoral Briareum excavatum, collected off southern Taiwan coast. The structures of these new metabolites were elucidated by the interpretation of spectroscopic and chemical methods. The configuration of 1 was further supported by molecular mechanics calculations. Briarane 1 has been shown to exhibit mild cytotoxicity toward MDA-MB-231 human breast tumor cells and briarane 3 was found to show activity to inhibit neutrophil elastase release in humans.",

keywords = "Briaexcavatin, Briarane, Briareum excavatum, Cytotoxicity, Human neutrophil elastase, Octocoral",

author = "Sung, \{Ping Jyun\} and Chen, \{Yu Pei\} and Hwang, \{Tsong Long\} and Hu, \{Wan Ping\} and Fang, \{Lee Shing\} and Wu, \{Yang Chang\} and Li, \{Jan Jung\} and Sheu, \{Jyh Horng\}",

year = "2006",

month = jun,

day = "12",

doi = "10.1016/j.tet.2006.03.086",

language = "英语",

volume = "62",

pages = "5686--5691",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "24",

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T1 - Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae)

AU - Sung, Ping Jyun

AU - Chen, Yu Pei

AU - Hwang, Tsong Long

AU - Hu, Wan Ping

AU - Fang, Lee Shing

AU - Wu, Yang Chang

AU - Li, Jan Jung

AU - Sheu, Jyh Horng

PY - 2006/6/12

Y1 - 2006/6/12

N2 - Four new briarane-related diterpenoids, designated as briaexcavatins C-F (1-4), were isolated from the Formosan octocoral Briareum excavatum, collected off southern Taiwan coast. The structures of these new metabolites were elucidated by the interpretation of spectroscopic and chemical methods. The configuration of 1 was further supported by molecular mechanics calculations. Briarane 1 has been shown to exhibit mild cytotoxicity toward MDA-MB-231 human breast tumor cells and briarane 3 was found to show activity to inhibit neutrophil elastase release in humans.

AB - Four new briarane-related diterpenoids, designated as briaexcavatins C-F (1-4), were isolated from the Formosan octocoral Briareum excavatum, collected off southern Taiwan coast. The structures of these new metabolites were elucidated by the interpretation of spectroscopic and chemical methods. The configuration of 1 was further supported by molecular mechanics calculations. Briarane 1 has been shown to exhibit mild cytotoxicity toward MDA-MB-231 human breast tumor cells and briarane 3 was found to show activity to inhibit neutrophil elastase release in humans.

KW - Briaexcavatin

KW - Briarane

KW - Briareum excavatum

KW - Cytotoxicity

KW - Human neutrophil elastase

KW - Octocoral

UR - https://www.scopus.com/pages/publications/33646365330

U2 - 10.1016/j.tet.2006.03.086

DO - 10.1016/j.tet.2006.03.086

M3 - 文章

AN - SCOPUS:33646365330

SN - 0040-4020

VL - 62

SP - 5686

EP - 5691

JO - Tetrahedron

JF - Tetrahedron

IS - 24

ER -

Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae)

Abstract

Keywords

UN SDGs

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