Briarenols C-E, new polyoxygenated briaranes from the octocoral briareum excavatum

Nan Fu Chen; Yin Di Su; Tsong Long Hwang; Zuo Jian Liao; Kuan Hao Tsui; Zhi Hong Wen; Yang Chang Wu; Ping Jyun Sung; Thomas J. Schmidt

doi:10.3390/molecules22030475

Briarenols C-E, new polyoxygenated briaranes from the octocoral briareum excavatum

Nan Fu Chen, Yin Di Su, Tsong Long Hwang, Zuo Jian Liao, Kuan Hao Tsui, Zhi Hong Wen, Yang Chang Wu, Ping Jyun Sung^*, Thomas J. Schmidt

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

Three new polyoxygenated briarane diterpenoids, briarenols C-E (1-3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC₅₀ value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).

Original language	English
Article number	475
Journal	Molecules
Volume	22
Issue number	3
DOIs	https://doi.org/10.3390/molecules22030475
State	Published - 03 2017

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© 2017 by the authors. Licensee MDPI, Basel, Switzerland.

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title = "Briarenols C-E, new polyoxygenated briaranes from the octocoral briareum excavatum",

abstract = "Three new polyoxygenated briarane diterpenoids, briarenols C-E (1-3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC50 value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).",

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doi = "10.3390/molecules22030475",

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AU - Chen, Nan Fu

AU - Su, Yin Di

AU - Hwang, Tsong Long

AU - Liao, Zuo Jian

AU - Tsui, Kuan Hao

AU - Wen, Zhi Hong

AU - Wu, Yang Chang

AU - Sung, Ping Jyun

AU - Schmidt, Thomas J.

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AB - Three new polyoxygenated briarane diterpenoids, briarenols C-E (1-3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC50 value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).

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Briarenols C-E, new polyoxygenated briaranes from the octocoral briareum excavatum

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