Briarenols Q-T: Briaranes from a cultured octocoral Briareum stechei (Kükenthal, 1908)

Yi Lin Zhang; Chih Chao Chiang; Yi Ting Lee; Zhi Hong Wen; Yang Chang Wu; Yu Jen Wu; Tsong Long Hwang; Tung Ying Wu; Chia Yuan Chang; Ping Jyun Sung

doi:10.3390/MD18080383

Briarenols Q-T: Briaranes from a cultured octocoral Briareum stechei (Kükenthal, 1908)

Yi Lin Zhang, Chih Chao Chiang, Yi Ting Lee, Zhi Hong Wen, Yang Chang Wu, Yu Jen Wu, Tsong Long Hwang, Tung Ying Wu^*, Chia Yuan Chang^*, Ping Jyun Sung^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q-T (1-4). The structures of new metabolites 1-4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).

Original language	English
Article number	383
Journal	Marine Drugs
Volume	18
Issue number	8
DOIs	https://doi.org/10.3390/MD18080383
State	Published - 07 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

Briarane
Briarenol
Briareum stechei
COX-2
INOS

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title = "Briarenols Q-T: Briaranes from a cultured octocoral Briareum stechei (K{\"u}kenthal, 1908)",

abstract = "Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q-T (1-4). The structures of new metabolites 1-4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).",

keywords = "Briarane, Briarenol, Briareum stechei, COX-2, INOS",

author = "Zhang, {Yi Lin} and Chiang, {Chih Chao} and Lee, {Yi Ting} and Wen, {Zhi Hong} and Wu, {Yang Chang} and Wu, {Yu Jen} and Hwang, {Tsong Long} and Wu, {Tung Ying} and Chang, {Chia Yuan} and Sung, {Ping Jyun}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",

year = "2020",

month = jul,

doi = "10.3390/MD18080383",

language = "英语",

volume = "18",

journal = "Marine Drugs",

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T2 - Briaranes from a cultured octocoral Briareum stechei (Kükenthal, 1908)

AU - Zhang, Yi Lin

AU - Chiang, Chih Chao

AU - Lee, Yi Ting

AU - Wen, Zhi Hong

AU - Wu, Yang Chang

AU - Wu, Yu Jen

AU - Hwang, Tsong Long

AU - Wu, Tung Ying

AU - Chang, Chia Yuan

AU - Sung, Ping Jyun

N1 - Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PY - 2020/7

Y1 - 2020/7

N2 - Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q-T (1-4). The structures of new metabolites 1-4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).

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KW - Briarane

KW - Briarenol

KW - Briareum stechei

KW - COX-2

KW - INOS

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U2 - 10.3390/MD18080383

DO - 10.3390/MD18080383

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SN - 1660-3397

VL - 18

JO - Marine Drugs

JF - Marine Drugs

IS - 8

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ER -

Briarenols Q-T: Briaranes from a cultured octocoral Briareum stechei (Kükenthal, 1908)

Abstract

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Keywords

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