Bundled skin antiseptic preparation for complex cardiac implantable electronic device infection: a propensity-score matching cohort study

H. C. Chen*, W. C. Lee, Y. L. Chen, T. H. Tsai, K. L. Pan, Y. S. Lin, M. C. Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

Background: Cardiac implantable electronic device (CIED) infection, a major complication of a CIED implant procedure, can prolong hospitalization and cause mortality. Aim: To evaluate the efficacy of a bundled skin antiseptic preparation for preventing infection after implantation of a complex CIED. Methods: This study analysed 1163 consecutive patients who had received a bundled skin antiseptic preparation before CIED implantation from July 2012 to December 2017. According to the complexity of the CIED implant procedure, the patients were divided into a complex CIED group (N = 370) and a non-complex CIED group (N = 793). A complex procedure was defined as a pacemaker replacement, implantation of implantable cardioverter defibrillator and cardiac resynchronization therapy, device upgrade, or lead revision. Findings: During a mean follow-up of 2.9 ± 1.7 years, CIED infection developed in 15 patients (1.3%), and the incidence of minor and major infection was 1.1% and 0.2%, respectively. The incidence of CIED infection did not significantly differ between the complex CIED group and the non-complex CIED group (1.1% vs 1.4%, respectively; non-significant). Multivariate analysis indicated that procedural complexity was not an independent predictor of CIED infection. After 2:1 propensity score matching, the matched non-complex CIED group and the matched complex CIED group still showed no significant difference in the incidence of CIED infection. Conclusion: Bundled skin antiseptic preparation is an effective and widely applicable strategy for decreasing infection risk after a complex CIED implantation.

Original languageEnglish
Pages (from-to)311-320
Number of pages10
JournalJournal of Hospital Infection
Volume103
Issue number3
DOIs
StatePublished - 11 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 The Author(s)

Keywords

  • Cardiac implantable device infection
  • Cardiac implantable electronic devices
  • Skin antiseptic preparation

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