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Cadmium and cardiovascular disease: An overview of pathophysiology, epidemiology, therapy, and predictive value

  • Hung Chen Lin
  • , Wei Ming Hao
  • , Pao Hsien Chu*
  • *Corresponding author for this work
  • Huashan Hospital
  • Fudan University
  • Chang Gung University

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

Cadmium is a widely distributed toxic heavy metal that has been associated with many diseases including chronic renal dysfunction, osteomalacia, acute heart failure, secondary hypertension, and atherosclerosis. Although several studies have suggested that cadmium may affect multiple systems by inducing lipid per oxidation in cells and disturbing the antioxidant system, the mechanism by which cadmium affects the cardiovascular system remains unclear. Recent studies on heart failure and acute myocardial infarction have shown that cadmium has good predictive ability for mortality in patients with cardiovascular disease. In this study, we briefly review the role of cadmium in cardiovascular disease, which may prompt further studies to investigate the potential association between cadmium and mortality in patients with cardiovascular disease.

Original languageEnglish
Pages (from-to)611-617
Number of pages7
JournalRevista Portuguesa de Cardiologia
Volume40
Issue number8
DOIs
StatePublished - 08 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 Sociedade Portuguesa de Cardiologia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Acute myocardial infarction
  • Cadmium
  • Cardiovascular disease
  • Heart failure

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