Calcium-ion–sensing cell-surface receptors

Jeffrey S. Flier; Lisa H. Underhill; Edward M. Brown; Martin Pollak; Christine E. Seidman; J. G. Seidman; ya Huei wu Chou; Daniela Riccardi; Steven C. Hebert

doi:10.1056/NEJM199507273330407

Calcium-ion–sensing cell-surface receptors

Jeffrey S. Flier, Lisa H. Underhill, Edward M. Brown, Martin Pollak, Christine E. Seidman, J. G. Seidman, ya Huei wu Chou, Daniela Riccardi, Steven C. Hebert

Research output: Contribution to journal › Review article › peer-review

251 Scopus citations

Abstract

Calcium ions are essential for a wide variety of biologic functions, including vital extracellular processes, such as blood clotting, intercellular adhesion, and skeletal integrity, as well as intracellular processes, such as the regulation of hormonal secretion, cell division, and cell motility.¹–⁴ Complex, free-living terrestrial organisms must maintain a near-constant concentration of extracellular calcium. How the body maintains and regulates extracellular calcium levels is a complex puzzle that has intrigued researchers for decades.³–⁵ One large piece of this puzzle that is falling into place concerns a cell-surface receptor that responds to, or “senses,” extracellular calcium-ion concentrations in parathyroid, kidney,.

Original language	English
Pages (from-to)	234-240
Number of pages	7
Journal	New England Journal of Medicine
Volume	333
Issue number	4
DOIs	https://doi.org/10.1056/NEJM199507273330407
State	Published - 27 07 1995
Externally published	Yes

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title = "Calcium-ion–sensing cell-surface receptors",

abstract = "Calcium ions are essential for a wide variety of biologic functions, including vital extracellular processes, such as blood clotting, intercellular adhesion, and skeletal integrity, as well as intracellular processes, such as the regulation of hormonal secretion, cell division, and cell motility.1–4 Complex, free-living terrestrial organisms must maintain a near-constant concentration of extracellular calcium. How the body maintains and regulates extracellular calcium levels is a complex puzzle that has intrigued researchers for decades.3–5 One large piece of this puzzle that is falling into place concerns a cell-surface receptor that responds to, or “senses,” extracellular calcium-ion concentrations in parathyroid, kidney,.",

author = "Flier, {Jeffrey S.} and Underhill, {Lisa H.} and Brown, {Edward M.} and Martin Pollak and Seidman, {Christine E.} and Seidman, {J. G.} and Chou, {ya Huei wu} and Daniela Riccardi and Hebert, {Steven C.}",

year = "1995",

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T1 - Calcium-ion–sensing cell-surface receptors

AU - Flier, Jeffrey S.

AU - Underhill, Lisa H.

AU - Brown, Edward M.

AU - Pollak, Martin

AU - Seidman, Christine E.

AU - Seidman, J. G.

AU - Chou, ya Huei wu

AU - Riccardi, Daniela

AU - Hebert, Steven C.

PY - 1995/7/27

Y1 - 1995/7/27

N2 - Calcium ions are essential for a wide variety of biologic functions, including vital extracellular processes, such as blood clotting, intercellular adhesion, and skeletal integrity, as well as intracellular processes, such as the regulation of hormonal secretion, cell division, and cell motility.1–4 Complex, free-living terrestrial organisms must maintain a near-constant concentration of extracellular calcium. How the body maintains and regulates extracellular calcium levels is a complex puzzle that has intrigued researchers for decades.3–5 One large piece of this puzzle that is falling into place concerns a cell-surface receptor that responds to, or “senses,” extracellular calcium-ion concentrations in parathyroid, kidney,.

AB - Calcium ions are essential for a wide variety of biologic functions, including vital extracellular processes, such as blood clotting, intercellular adhesion, and skeletal integrity, as well as intracellular processes, such as the regulation of hormonal secretion, cell division, and cell motility.1–4 Complex, free-living terrestrial organisms must maintain a near-constant concentration of extracellular calcium. How the body maintains and regulates extracellular calcium levels is a complex puzzle that has intrigued researchers for decades.3–5 One large piece of this puzzle that is falling into place concerns a cell-surface receptor that responds to, or “senses,” extracellular calcium-ion concentrations in parathyroid, kidney,.

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JO - New England Journal of Medicine

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Calcium-ion–sensing cell-surface receptors

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