Camphorataimide B suppresses the metastasis of human colorectal cancer cell by inhibiting Smad/FAK/ Akt axis and promoting degradation of Snail/ BMP4 complex

Chi Chou Huang; Chia Hung Hung; Yi Ju Lee; Tsui Hwa Tseng; Yean Jang Lee; Shao Hsuan Kao; Chau Jong Wang

doi:10.38212/2224-6614.3405

Camphorataimide B suppresses the metastasis of human colorectal cancer cell by inhibiting Smad/FAK/ Akt axis and promoting degradation of Snail/ BMP4 complex

Chi Chou Huang
, Chia Hung Hung
, Yi Ju Lee
, Tsui Hwa Tseng
, Yean Jang Lee
, Shao Hsuan Kao^*
, Chau Jong Wang^*

^*Corresponding author for this work

Chung Shan Medical University
National Changhua University of Education

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

Camphorataimide B (CamB) has anticancer activities against several tumors. Here, we aimed to investigate the mechanism(s) by which CamB inhibits metastasis of colorectal cancer (CRC) cells. Low-dose CamB did not affect the cell viability and cell cycle progression of CRC cells, but significantly inhibited the metastatic potentials of CRC cells. Mechanically, CamB reduced the protein and mRNA expression of BMP4, and inhibited Smad and FAK/Src/Akt signaling. CamB also decreased Snail levels by promoting its degradation via proteasome and thereafter reduced Snail-mediated BMP4 transcription. Moreover, CamB considerably inhibited the in vivo metastasis of DLD-1 cells in xenograft mice.

Original language	English
Pages (from-to)	271-282
Number of pages	12
Journal	Journal of Food and Drug Analysis
Volume	30
Issue number	2
DOIs	https://doi.org/10.38212/2224-6614.3405
State	Published - 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bone morphogenetic protein 4
Camphorataimide-B
Colorectal cancer
FAK
Snail

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10.38212/2224-6614.3405

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title = "Camphorataimide B suppresses the metastasis of human colorectal cancer cell by inhibiting Smad/FAK/ Akt axis and promoting degradation of Snail/ BMP4 complex",

abstract = "Camphorataimide B (CamB) has anticancer activities against several tumors. Here, we aimed to investigate the mechanism(s) by which CamB inhibits metastasis of colorectal cancer (CRC) cells. Low-dose CamB did not affect the cell viability and cell cycle progression of CRC cells, but significantly inhibited the metastatic potentials of CRC cells. Mechanically, CamB reduced the protein and mRNA expression of BMP4, and inhibited Smad and FAK/Src/Akt signaling. CamB also decreased Snail levels by promoting its degradation via proteasome and thereafter reduced Snail-mediated BMP4 transcription. Moreover, CamB considerably inhibited the in vivo metastasis of DLD-1 cells in xenograft mice.",

keywords = "Bone morphogenetic protein 4, Camphorataimide-B, Colorectal cancer, FAK, Snail",

author = "Huang, \{Chi Chou\} and Hung, \{Chia Hung\} and Lee, \{Yi Ju\} and Tseng, \{Tsui Hwa\} and Lee, \{Yean Jang\} and Kao, \{Shao Hsuan\} and Wang, \{Chau Jong\}",

note = "Publisher Copyright: {\textcopyright} 2022.",

year = "2022",

doi = "10.38212/2224-6614.3405",

language = "英语",

volume = "30",

pages = "271--282",

journal = "Journal of Food and Drug Analysis",

issn = "1021-9498",

publisher = "National Laboratories of Foods and Drugs",

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}

TY - JOUR

T1 - Camphorataimide B suppresses the metastasis of human colorectal cancer cell by inhibiting Smad/FAK/ Akt axis and promoting degradation of Snail/ BMP4 complex

AU - Huang, Chi Chou

AU - Hung, Chia Hung

AU - Lee, Yi Ju

AU - Tseng, Tsui Hwa

AU - Lee, Yean Jang

AU - Kao, Shao Hsuan

AU - Wang, Chau Jong

PY - 2022

Y1 - 2022

N2 - Camphorataimide B (CamB) has anticancer activities against several tumors. Here, we aimed to investigate the mechanism(s) by which CamB inhibits metastasis of colorectal cancer (CRC) cells. Low-dose CamB did not affect the cell viability and cell cycle progression of CRC cells, but significantly inhibited the metastatic potentials of CRC cells. Mechanically, CamB reduced the protein and mRNA expression of BMP4, and inhibited Smad and FAK/Src/Akt signaling. CamB also decreased Snail levels by promoting its degradation via proteasome and thereafter reduced Snail-mediated BMP4 transcription. Moreover, CamB considerably inhibited the in vivo metastasis of DLD-1 cells in xenograft mice.

AB - Camphorataimide B (CamB) has anticancer activities against several tumors. Here, we aimed to investigate the mechanism(s) by which CamB inhibits metastasis of colorectal cancer (CRC) cells. Low-dose CamB did not affect the cell viability and cell cycle progression of CRC cells, but significantly inhibited the metastatic potentials of CRC cells. Mechanically, CamB reduced the protein and mRNA expression of BMP4, and inhibited Smad and FAK/Src/Akt signaling. CamB also decreased Snail levels by promoting its degradation via proteasome and thereafter reduced Snail-mediated BMP4 transcription. Moreover, CamB considerably inhibited the in vivo metastasis of DLD-1 cells in xenograft mice.

KW - Bone morphogenetic protein 4

KW - Camphorataimide-B

KW - Colorectal cancer

KW - FAK

KW - Snail

UR - https://www.scopus.com/pages/publications/85132564171

U2 - 10.38212/2224-6614.3405

DO - 10.38212/2224-6614.3405

M3 - 文章

AN - SCOPUS:85132564171

SN - 1021-9498

VL - 30

SP - 271

EP - 282

JO - Journal of Food and Drug Analysis

JF - Journal of Food and Drug Analysis

IS - 2

ER -

Camphorataimide B suppresses the metastasis of human colorectal cancer cell by inhibiting Smad/FAK/ Akt axis and promoting degradation of Snail/ BMP4 complex

Abstract

Bibliographical note

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Keywords

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