Abstract
NPM1 gene mutation evaluated on a population basis is a valuable and realistic tool to reflect the pathophysiological relevance of cancer. In a comparison of the NPM1 cDNA of human bladder cancer with its consensus sequence, we have found that a higher NPM1 sequence identity in a population is consistent with poor tumor differentiation, advanced tumor stage, and likelihood of recurrence. These data imply that "probability" of NPM1 mutation is an indicator of status of malignancy.
| Original language | English |
|---|---|
| Pages (from-to) | 746-750 |
| Number of pages | 5 |
| Journal | Genomics |
| Volume | 90 |
| Issue number | 6 |
| DOIs | |
| State | Published - 12 2007 |
Keywords
- Gene identity
- Genetic variations
- Nucleophosmin
- Population genetics
- Probability of mutation
