Cancer related fatigue-light therapy: updated meta-analysis of randomised controlled trials

Chao Ming Hung; Bing Yan Zeng; Bing Syuan Zeng; Cheuk Kwan Sun; Yu Shian Cheng; Kuan Pin Su; Yi Cheng Wu; Tien Yu Chen; Pao Yen Lin; Chih Sung Liang; Chih Wei Hsu; Che Sheng Chu; Yen Wen Chen; Pin Yang Yeh; Ming Kung Wu; Ping Tao Tseng; Yutaka J. Matsuoka

doi:10.1136/bmjspcare-2021-003135

Cancer related fatigue-light therapy: updated meta-analysis of randomised controlled trials

Chao Ming Hung, Bing Yan Zeng, Bing Syuan Zeng, Cheuk Kwan Sun, Yu Shian Cheng, Kuan Pin Su, Yi Cheng Wu, Tien Yu Chen, Pao Yen Lin, Chih Sung Liang, Chih Wei Hsu, Che Sheng Chu, Yen Wen Chen, Pin Yang Yeh, Ming Kung Wu^*, Ping Tao Tseng^*, Yutaka J. Matsuoka^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

Background Moderate-to-severe cancer related fatigue occurs in 45% of patients with cancer and interferes with many aspects of quality of life. Although physical exercise has level 1 evidence for improvement of cancer related fatigue, it has a relatively high behavioural demand compared with other non-pharmacological interventions. The aim of this updated meta-analysis was to address the efficacy of light therapy in improving cancer related fatigue in patients with cancer. Methods We included randomised controlled trials investigating the efficacy of bright white light (BWL) therapy in ameliorating cancer related fatigue in patients with cancer. This meta-analysis was conducted using a random-effects model. The target outcomes were changes in cancer related fatigue associated with BWL or dim red light (DRL). Results There were 9 articles with 231 participants included. The main results revealed that daily morning BWL for 30 min was associated with significantly better improvement in fatigue severity compared with DRL (k=5, Hedges' g=-0.414, 95% CI -0.740 to -0.087, p=0.013). The subgroup without psychiatric comorbidities (k=4, Hedges' g=-0.479, 95% CI -0.801 to -0.156, p=0.004) was associated with significantly better improvement in fatigue severity with BWL than with DRL. In contrary, BWL was not associated with significantly different changes in depression severity or quality of life compared with DRL. Finally, BWL was associated with similar acceptability (ie, dropout rate) and safety profile (ie, any discomfort) as those of DRL. Conclusions This meta-analysis provides an updated evidence on the rationale for application of BWL in ameliorating cancer related fatigue in patients with different types of cancer.

Original language	English
Pages (from-to)	E437-E445
Journal	BMJ Supportive and Palliative Care
Volume	13
Issue number	e2
DOIs	https://doi.org/10.1136/bmjspcare-2021-003135
State	Published - 15 07 2021

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Publisher Copyright:
© Author(s) (or their employer(s)) 2023.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Hung, C. M., Zeng, B. Y., Zeng, B. S., Sun, C. K., Cheng, Y. S., Su, K. P., Wu, Y. C., Chen, T. Y., Lin, P. Y., Liang, C. S., Hsu, C. W., Chu, C. S., Chen, Y. W., Yeh, P. Y., Wu, M. K., Tseng, P. T., & Matsuoka, Y. J. (2021). Cancer related fatigue-light therapy: updated meta-analysis of randomised controlled trials. BMJ Supportive and Palliative Care, 13(e2), E437-E445. https://doi.org/10.1136/bmjspcare-2021-003135

@article{6f88d6a966eb422f8efd73c7497a3720,

title = "Cancer related fatigue-light therapy: updated meta-analysis of randomised controlled trials",

abstract = "Background Moderate-to-severe cancer related fatigue occurs in 45% of patients with cancer and interferes with many aspects of quality of life. Although physical exercise has level 1 evidence for improvement of cancer related fatigue, it has a relatively high behavioural demand compared with other non-pharmacological interventions. The aim of this updated meta-analysis was to address the efficacy of light therapy in improving cancer related fatigue in patients with cancer. Methods We included randomised controlled trials investigating the efficacy of bright white light (BWL) therapy in ameliorating cancer related fatigue in patients with cancer. This meta-analysis was conducted using a random-effects model. The target outcomes were changes in cancer related fatigue associated with BWL or dim red light (DRL). Results There were 9 articles with 231 participants included. The main results revealed that daily morning BWL for 30 min was associated with significantly better improvement in fatigue severity compared with DRL (k=5, Hedges' g=-0.414, 95% CI -0.740 to -0.087, p=0.013). The subgroup without psychiatric comorbidities (k=4, Hedges' g=-0.479, 95% CI -0.801 to -0.156, p=0.004) was associated with significantly better improvement in fatigue severity with BWL than with DRL. In contrary, BWL was not associated with significantly different changes in depression severity or quality of life compared with DRL. Finally, BWL was associated with similar acceptability (ie, dropout rate) and safety profile (ie, any discomfort) as those of DRL. Conclusions This meta-analysis provides an updated evidence on the rationale for application of BWL in ameliorating cancer related fatigue in patients with different types of cancer.",

author = "Hung, {Chao Ming} and Zeng, {Bing Yan} and Zeng, {Bing Syuan} and Sun, {Cheuk Kwan} and Cheng, {Yu Shian} and Su, {Kuan Pin} and Wu, {Yi Cheng} and Chen, {Tien Yu} and Lin, {Pao Yen} and Liang, {Chih Sung} and Hsu, {Chih Wei} and Chu, {Che Sheng} and Chen, {Yen Wen} and Yeh, {Pin Yang} and Wu, {Ming Kung} and Tseng, {Ping Tao} and Matsuoka, {Yutaka J.}",

note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2023.",

year = "2021",

month = jul,

day = "15",

doi = "10.1136/bmjspcare-2021-003135",

language = "英语",

volume = "13",

pages = "E437--E445",

journal = "BMJ Supportive and Palliative Care",

issn = "2045-435X",

publisher = "BMJ Publishing Group",

number = "e2",

}

Hung, CM, Zeng, BY, Zeng, BS, Sun, CK, Cheng, YS, Su, KP, Wu, YC, Chen, TY, Lin, PY, Liang, CS, Hsu, CW, Chu, CS, Chen, YW, Yeh, PY, Wu, MK, Tseng, PT & Matsuoka, YJ 2021, 'Cancer related fatigue-light therapy: updated meta-analysis of randomised controlled trials', BMJ Supportive and Palliative Care, vol. 13, no. e2, pp. E437-E445. https://doi.org/10.1136/bmjspcare-2021-003135

TY - JOUR

T1 - Cancer related fatigue-light therapy

T2 - updated meta-analysis of randomised controlled trials

AU - Hung, Chao Ming

AU - Zeng, Bing Yan

AU - Zeng, Bing Syuan

AU - Sun, Cheuk Kwan

AU - Cheng, Yu Shian

AU - Su, Kuan Pin

AU - Wu, Yi Cheng

AU - Chen, Tien Yu

AU - Lin, Pao Yen

AU - Liang, Chih Sung

AU - Hsu, Chih Wei

AU - Chu, Che Sheng

AU - Chen, Yen Wen

AU - Yeh, Pin Yang

AU - Wu, Ming Kung

AU - Tseng, Ping Tao

AU - Matsuoka, Yutaka J.

PY - 2021/7/15

Y1 - 2021/7/15

N2 - Background Moderate-to-severe cancer related fatigue occurs in 45% of patients with cancer and interferes with many aspects of quality of life. Although physical exercise has level 1 evidence for improvement of cancer related fatigue, it has a relatively high behavioural demand compared with other non-pharmacological interventions. The aim of this updated meta-analysis was to address the efficacy of light therapy in improving cancer related fatigue in patients with cancer. Methods We included randomised controlled trials investigating the efficacy of bright white light (BWL) therapy in ameliorating cancer related fatigue in patients with cancer. This meta-analysis was conducted using a random-effects model. The target outcomes were changes in cancer related fatigue associated with BWL or dim red light (DRL). Results There were 9 articles with 231 participants included. The main results revealed that daily morning BWL for 30 min was associated with significantly better improvement in fatigue severity compared with DRL (k=5, Hedges' g=-0.414, 95% CI -0.740 to -0.087, p=0.013). The subgroup without psychiatric comorbidities (k=4, Hedges' g=-0.479, 95% CI -0.801 to -0.156, p=0.004) was associated with significantly better improvement in fatigue severity with BWL than with DRL. In contrary, BWL was not associated with significantly different changes in depression severity or quality of life compared with DRL. Finally, BWL was associated with similar acceptability (ie, dropout rate) and safety profile (ie, any discomfort) as those of DRL. Conclusions This meta-analysis provides an updated evidence on the rationale for application of BWL in ameliorating cancer related fatigue in patients with different types of cancer.

AB - Background Moderate-to-severe cancer related fatigue occurs in 45% of patients with cancer and interferes with many aspects of quality of life. Although physical exercise has level 1 evidence for improvement of cancer related fatigue, it has a relatively high behavioural demand compared with other non-pharmacological interventions. The aim of this updated meta-analysis was to address the efficacy of light therapy in improving cancer related fatigue in patients with cancer. Methods We included randomised controlled trials investigating the efficacy of bright white light (BWL) therapy in ameliorating cancer related fatigue in patients with cancer. This meta-analysis was conducted using a random-effects model. The target outcomes were changes in cancer related fatigue associated with BWL or dim red light (DRL). Results There were 9 articles with 231 participants included. The main results revealed that daily morning BWL for 30 min was associated with significantly better improvement in fatigue severity compared with DRL (k=5, Hedges' g=-0.414, 95% CI -0.740 to -0.087, p=0.013). The subgroup without psychiatric comorbidities (k=4, Hedges' g=-0.479, 95% CI -0.801 to -0.156, p=0.004) was associated with significantly better improvement in fatigue severity with BWL than with DRL. In contrary, BWL was not associated with significantly different changes in depression severity or quality of life compared with DRL. Finally, BWL was associated with similar acceptability (ie, dropout rate) and safety profile (ie, any discomfort) as those of DRL. Conclusions This meta-analysis provides an updated evidence on the rationale for application of BWL in ameliorating cancer related fatigue in patients with different types of cancer.

UR - http://www.scopus.com/inward/record.url?scp=85110552025&partnerID=8YFLogxK

U2 - 10.1136/bmjspcare-2021-003135

DO - 10.1136/bmjspcare-2021-003135

M3 - 文章

C2 - 34266911

AN - SCOPUS:85110552025

SN - 2045-435X

VL - 13

SP - E437-E445

JO - BMJ Supportive and Palliative Care

JF - BMJ Supportive and Palliative Care

IS - e2

ER -

Cancer related fatigue-light therapy: updated meta-analysis of randomised controlled trials

Abstract

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