TY - JOUR
T1 - Candida peritonitis due to peptic ulcer perforation
T2 - Incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B
AU - Lee, Sai Cheong
AU - Fung, Chang Phone
AU - Chen, Huang Yang
AU - Li, Chiung Tsung
AU - Jwo, Shyh Chuan
AU - Hung, Yi Ben
AU - See, Lai Chu
AU - Liao, How Chin
AU - Loke, Song Seng
AU - Wang, Feng Lin
AU - Lee, Jenq Chang
PY - 2002/9
Y1 - 2002/9
N2 - Sixty-two cases of peritonitis due to peptic ulcer perforation were diagnosed between January 2000 and December 2000. Of these 62 cases, 23 isolates of Candida in 23 cases (CP) were cultured from peritoneal fluid. Cultures of peritoneal fluid of 10 (BP) of the remaining 39 cases was positive for bacteria only. Cultures of peritoneal fluid of the remaining 29 cases was negative. Comparison of CP, BP and culture-negative cases did not reveal any significant risk factor. Of the 23 Candida isolates, the Candida species and 48-h MICs of fluconazole and amphotericin B (mean, range ug/ml) were C. albicans 18 (0.688, 0.125-1.0; 0.297, 0.031-0.5), C. glabrata 3 (0.542, 0.125-1.0; 0.25, 0.125-0.5), C. tropicalis 1 (0.25; 0.5), C. intermedia 1 (1.0; 0.125) respectively. Mortality rates of CP, BP and culture-negative peritonitis due to infection were 5/23(21.7%), 0/10 and 1/29(3.4%) respectively. Without effective antifungal therapy, the mortality rate of CP was not low.
AB - Sixty-two cases of peritonitis due to peptic ulcer perforation were diagnosed between January 2000 and December 2000. Of these 62 cases, 23 isolates of Candida in 23 cases (CP) were cultured from peritoneal fluid. Cultures of peritoneal fluid of 10 (BP) of the remaining 39 cases was positive for bacteria only. Cultures of peritoneal fluid of the remaining 29 cases was negative. Comparison of CP, BP and culture-negative cases did not reveal any significant risk factor. Of the 23 Candida isolates, the Candida species and 48-h MICs of fluconazole and amphotericin B (mean, range ug/ml) were C. albicans 18 (0.688, 0.125-1.0; 0.297, 0.031-0.5), C. glabrata 3 (0.542, 0.125-1.0; 0.25, 0.125-0.5), C. tropicalis 1 (0.25; 0.5), C. intermedia 1 (1.0; 0.125) respectively. Mortality rates of CP, BP and culture-negative peritonitis due to infection were 5/23(21.7%), 0/10 and 1/29(3.4%) respectively. Without effective antifungal therapy, the mortality rate of CP was not low.
UR - http://www.scopus.com/inward/record.url?scp=0036746019&partnerID=8YFLogxK
U2 - 10.1016/S0732-8893(02)00419-4
DO - 10.1016/S0732-8893(02)00419-4
M3 - 文章
C2 - 12376027
AN - SCOPUS:0036746019
SN - 0732-8893
VL - 44
SP - 23
EP - 27
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 1
M1 - 10895
ER -
