Capsisteroids A-F, withanolides from the leaves of Solanum capsicoides

Bo Wei Chen; Yang Yih Chen; You Cheng Lin; Chiung Yao Huang; Chokkalingam Uvarani; Tsong Long Hwang; Michael Y. Chiang; Ho Yih Liu; Jyh Horng Sheu

doi:10.1039/c5ra12014d

Capsisteroids A-F, withanolides from the leaves of Solanum capsicoides

Bo Wei Chen, Yang Yih Chen, You Cheng Lin, Chiung Yao Huang, Chokkalingam Uvarani, Tsong Long Hwang, Michael Y. Chiang, Ho Yih Liu, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

A known withanolide steroid cilistol G (1) and six new withanolides, capsisteroids A-F (2-7), were isolated from the EtOAc extract of the leaves of Solanum capsicoides. The structures of compounds 1-7 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). The structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. These compounds were found not to be cytotoxic toward a limited panel of cancer cell lines. Further, the anti-inflammatory activity of compounds 1-7 was studied by measuring their ability to suppress superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

Original language	English
Pages (from-to)	88841-88847
Number of pages	7
Journal	RSC Advances
Volume	5
Issue number	108
DOIs	https://doi.org/10.1039/c5ra12014d
State	Published - 2015

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Publisher Copyright:
© 2015 The Royal Society of Chemistry.

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@article{f56ed27067c04fa6bd94ba1b6cd3b771,

title = "Capsisteroids A-F, withanolides from the leaves of Solanum capsicoides",

abstract = "A known withanolide steroid cilistol G (1) and six new withanolides, capsisteroids A-F (2-7), were isolated from the EtOAc extract of the leaves of Solanum capsicoides. The structures of compounds 1-7 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). The structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. These compounds were found not to be cytotoxic toward a limited panel of cancer cell lines. Further, the anti-inflammatory activity of compounds 1-7 was studied by measuring their ability to suppress superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.",

author = "Chen, \{Bo Wei\} and Chen, \{Yang Yih\} and Lin, \{You Cheng\} and Huang, \{Chiung Yao\} and Chokkalingam Uvarani and Hwang, \{Tsong Long\} and Chiang, \{Michael Y.\} and Liu, \{Ho Yih\} and Sheu, \{Jyh Horng\}",

note = "Publisher Copyright: {\textcopyright} 2015 The Royal Society of Chemistry.",

year = "2015",

doi = "10.1039/c5ra12014d",

language = "英语",

volume = "5",

pages = "88841--88847",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "108",

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TY - JOUR

T1 - Capsisteroids A-F, withanolides from the leaves of Solanum capsicoides

AU - Chen, Bo Wei

AU - Chen, Yang Yih

AU - Lin, You Cheng

AU - Huang, Chiung Yao

AU - Uvarani, Chokkalingam

AU - Hwang, Tsong Long

AU - Chiang, Michael Y.

AU - Liu, Ho Yih

AU - Sheu, Jyh Horng

PY - 2015

Y1 - 2015

N2 - A known withanolide steroid cilistol G (1) and six new withanolides, capsisteroids A-F (2-7), were isolated from the EtOAc extract of the leaves of Solanum capsicoides. The structures of compounds 1-7 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). The structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. These compounds were found not to be cytotoxic toward a limited panel of cancer cell lines. Further, the anti-inflammatory activity of compounds 1-7 was studied by measuring their ability to suppress superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

AB - A known withanolide steroid cilistol G (1) and six new withanolides, capsisteroids A-F (2-7), were isolated from the EtOAc extract of the leaves of Solanum capsicoides. The structures of compounds 1-7 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). The structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. These compounds were found not to be cytotoxic toward a limited panel of cancer cell lines. Further, the anti-inflammatory activity of compounds 1-7 was studied by measuring their ability to suppress superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

UR - https://www.scopus.com/pages/publications/84945579141

U2 - 10.1039/c5ra12014d

DO - 10.1039/c5ra12014d

M3 - 文章

AN - SCOPUS:84945579141

SN - 2046-2069

VL - 5

SP - 88841

EP - 88847

JO - RSC Advances

JF - RSC Advances

IS - 108

ER -

Capsisteroids A-F, withanolides from the leaves of Solanum capsicoides

Abstract

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