CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral cancer

Yu Chuan Lin, Chun Hung Hua, Hsin Man Lu, Shi Wei Huang, Yeh Chen, Ming Hsui Tsai, Fang Yu Lin, Peter Canoll, Shao Chih Chiu, Wei Hua Huang, Der Yang Cho, Chia Ing Jan*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

Oral squamous cell carcinoma (OSCC) is a common malignancy in the world. Recently, scientists have focused on therapeutic strategies to determine the regulation of tumors and design molecules for specific targets. Some studies have demonstrated the clinical significance of human leukocyte antigen G (HLA-G) in malignancy and NLR family pyrin domain-containing 3 (NLRP3) inflammasome in promoting tumorigenesis in OSCC. This is the first study to investigate whether aberrant epidermal growth factor receptor (EGFR) induces HLA-G expression through NLRP3 inflammasome-mediated IL-1β secretion in OSCC. Our results showed that the upregulation of NLRP3 inflammasome leads to abundant HLA-G in the cytoplasm and cell membrane of FaDu cells. In addition, we also generated anti-HLA-G chimeric antigen receptor (CAR)-T cells and provided evidence for their effects in EGFR-mutated and overexpressed oral cancer. Our results may be integrated with OSCC patient data to translate basic research into clinical significance and may lead to novel EGFR-aberrant OSCC treatment.

Original languageEnglish
Article number106089
Pages (from-to)106089
JournaliScience
Volume26
Issue number3
DOIs
StatePublished - 17 03 2023

Bibliographical note

© 2023 The Author(s).

Keywords

  • Cancer
  • Cell biology
  • Immunology
  • Molecular biology

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