Carcinogenesis in the biliary system associated with APDJ

Tzu Chieh Chao*, Chia Siu Wang, Yi Yin Jan, Han Ming Chen, Miin Fu Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

24 Scopus citations


Anomalous pancreaticobiliary ductal junction (APDJ) is a rare congenital anomaly which is considered to be an etiological factor in the development of carcinoma of the biliary tract. It is generally accepted that pancreatic juice reflux into the biliary tract due to APDJ is one of the etiologies of biliary tract cancers. Refluxing pancreatic juice results in changes of bile and induces chronic inflammation and increased cellular proliferation, leading to epithelial hyperplasia, metaplasia, and carcinoma of the biliary tract. K-ras mutations are more prevalent in the carcinomas of biliary tract associated with APDJ compared with those without APDJ. There is no difference in the overexpression of p53 between biliary tract carcinomas associated with APDJ and those unassociated with APDJ. Further studies are needed to evaluate the role of cytokines and growth factors in carcinogenesis of the biliary system associated with APDJ.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Issue number3
StatePublished - 1999


  • Bile duct
  • Carcinoma
  • Gallbladder
  • K-ras
  • p53


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