Carcinoid tumor of the thymus with divergent sarcomatoid differentiation: Report of a case with histogenetic consideration

Tseng tong Kuo*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

34 Scopus citations

Abstract

An anterior mediastinal tumor resected from a 54-year-old man without paraneoplastic symptoms was found to be an unusual biphasic thymic tumor composed of carcinoid tumor in sarcomatous stroma characterized by fibrosarcoma-like spindle cells with areas of chondroid and osseous differentiation. Immunohistochemical and ultrastructural studies verified that the tumor described was a carcinoid tumor with divergent sarcomatoid differentiation rather than a mixed carcinoid tumor and sarcoma. The chondroid and osseous differentiations observed were unique features. This tumor is rare and provides an opportunity for understanding tumors with divergent components. The sarcomatoid transformation of thymic carcinoid tumor might denote highly malignant clinical behavior as illustrated by this case.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalHuman Pathology
Volume25
Issue number3
DOIs
StatePublished - 03 1994

Keywords

  • carcinoid tumor
  • sarcomatoid carcinoid tumor
  • sarcomatoid differentiation
  • thymus

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