Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes

Li Man Hung, Jan Kan Chen, Shiang Suo Huang, Ren Shen Lee, Ming Jai Su*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

539 Scopus citations


Background: The major objective of the present study was to examine the cardioprotective effect of resveratrol, an antioxidant presents in red wines, in the rat after ischemia and ischemia-reperfusion (I-R). Methods: The left main coronary artery was occluded for 30 or 5 min followed by a 30-min reperfusion in anesthetized rats. Animals were preinfused with and without resveratrol before occlusion and the severity of ischemia- and I-R-induced arrhythmias and mortality were compared. Results: Resveratrol pretreatment had no effect on ischemia-induced arrhythmias nor on mortality. In contrast, a dramatic protective effects were observed against I-R-induced arrhythmias and mortality. Resveratrol pretreatment both reduced the incidence and duration of ventricular tachycardia (VT) and ventricular fibrillation (VF). During the same period, resveratrol pretreatment also increased nitric oxide (NO) and decreased lactate dehydrogenase levels in the carotid blood. Conclusions: Resveratrol is a potent antiarrhythmic agent with cardioprotective properties in I-R rats. The cardioprotective effects of resveratrol in the I-R rats may be correlated with its antioxidant activity and upregulation of NO production. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalCardiovascular Research
Issue number3
StatePublished - 18 08 2000


  • Arrhythmia, mechanisms
  • Free radicals
  • Ischemia
  • Nitric oxide
  • Reperfusion


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