Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)

Chih Yang Liu; Tsong Long Hwang; Mei Ru Lin; Yung Husan Chen; Yu Chia Chang; Lee Shing Fang; Wei Hsien Wang; Yang Chang Wu; Ping Jyun Sung

doi:10.3390/md8072014

Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)

Chih Yang Liu, Tsong Long Hwang, Mei Ru Lin, Yung Husan Chen, Yu Chia Chang, Lee Shing Fang, Wei Hsien Wang, Yang Chang Wu^*, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

24 Scopus citations

Abstract

A new bioactive sterol glycoside, 3 β-O-(3′,4′-di-O- acetyl- β-D-arabinopyranosyl) -25 ξ-cholestane-3 β,5 α,6 β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.

Original language	English
Pages (from-to)	2014-2020
Number of pages	7
Journal	Marine Drugs
Volume	8
Issue number	7
DOIs	https://doi.org/10.3390/md8072014
State	Published - 07 2010

Keywords

Carijoa
Carijoside
Cytotoxicity
Elastase
Glycoside
Superoxide anion

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title = "Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)",

abstract = "A new bioactive sterol glycoside, 3 β-O-(3′,4′-di-O- acetyl- β-D-arabinopyranosyl) -25 ξ-cholestane-3 β,5 α,6 β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.",

keywords = "Carijoa, Carijoside, Cytotoxicity, Elastase, Glycoside, Superoxide anion",

author = "Liu, {Chih Yang} and Hwang, {Tsong Long} and Lin, {Mei Ru} and Chen, {Yung Husan} and Chang, {Yu Chia} and Fang, {Lee Shing} and Wang, {Wei Hsien} and Wu, {Yang Chang} and Sung, {Ping Jyun}",

year = "2010",

month = jul,

doi = "10.3390/md8072014",

language = "英语",

volume = "8",

pages = "2014--2020",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)

AU - Liu, Chih Yang

AU - Hwang, Tsong Long

AU - Lin, Mei Ru

AU - Chen, Yung Husan

AU - Chang, Yu Chia

AU - Fang, Lee Shing

AU - Wang, Wei Hsien

AU - Wu, Yang Chang

AU - Sung, Ping Jyun

PY - 2010/7

Y1 - 2010/7

N2 - A new bioactive sterol glycoside, 3 β-O-(3′,4′-di-O- acetyl- β-D-arabinopyranosyl) -25 ξ-cholestane-3 β,5 α,6 β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.

AB - A new bioactive sterol glycoside, 3 β-O-(3′,4′-di-O- acetyl- β-D-arabinopyranosyl) -25 ξ-cholestane-3 β,5 α,6 β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.

KW - Carijoa

KW - Carijoside

KW - Cytotoxicity

KW - Elastase

KW - Glycoside

KW - Superoxide anion

UR - http://www.scopus.com/inward/record.url?scp=77955284769&partnerID=8YFLogxK

U2 - 10.3390/md8072014

DO - 10.3390/md8072014

M3 - 文章

C2 - 20714421

AN - SCOPUS:77955284769

SN - 1660-3397

VL - 8

SP - 2014

EP - 2020

JO - Marine Drugs

JF - Marine Drugs

IS - 7

ER -

Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)

Abstract

Keywords

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