Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)

Chih Yang Liu; Tsong Long Hwang; Mei Ru Lin; Yung Husan Chen; Yu Chia Chang; Lee Shing Fang; Wei Hsien Wang; Yang Chang Wu; Ping Jyun Sung

doi:10.3390/md8072014

Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)

Chih Yang Liu
, Tsong Long Hwang
, Mei Ru Lin
, Yung Husan Chen
, Yu Chia Chang
, Lee Shing Fang
, Wei Hsien Wang
, Yang Chang Wu^*
, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

A new bioactive sterol glycoside, 3 β-O-(3′,4′-di-O- acetyl- β-D-arabinopyranosyl) -25 ξ-cholestane-3 β,5 α,6 β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.

Original language	English
Pages (from-to)	2014-2020
Number of pages	7
Journal	Marine Drugs
Volume	8
Issue number	7
DOIs	https://doi.org/10.3390/md8072014
State	Published - 07 2010

Keywords

Carijoa
Carijoside
Cytotoxicity
Elastase
Glycoside
Superoxide anion

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10.3390/md8072014

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@article{3df5a48e19174cb5ab616a7c894ca6a3,

title = "Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)",

abstract = "A new bioactive sterol glycoside, 3 β-O-(3′,4′-di-O- acetyl- β-D-arabinopyranosyl) -25 ξ-cholestane-3 β,5 α,6 β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.",

keywords = "Carijoa, Carijoside, Cytotoxicity, Elastase, Glycoside, Superoxide anion",

author = "Liu, \{Chih Yang\} and Hwang, \{Tsong Long\} and Lin, \{Mei Ru\} and Chen, \{Yung Husan\} and Chang, \{Yu Chia\} and Fang, \{Lee Shing\} and Wang, \{Wei Hsien\} and Wu, \{Yang Chang\} and Sung, \{Ping Jyun\}",

year = "2010",

month = jul,

doi = "10.3390/md8072014",

language = "英语",

volume = "8",

pages = "2014--2020",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

TY - JOUR

T1 - Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)

AU - Liu, Chih Yang

AU - Hwang, Tsong Long

AU - Lin, Mei Ru

AU - Chen, Yung Husan

AU - Chang, Yu Chia

AU - Fang, Lee Shing

AU - Wang, Wei Hsien

AU - Wu, Yang Chang

AU - Sung, Ping Jyun

PY - 2010/7

Y1 - 2010/7

N2 - A new bioactive sterol glycoside, 3 β-O-(3′,4′-di-O- acetyl- β-D-arabinopyranosyl) -25 ξ-cholestane-3 β,5 α,6 β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.

AB - A new bioactive sterol glycoside, 3 β-O-(3′,4′-di-O- acetyl- β-D-arabinopyranosyl) -25 ξ-cholestane-3 β,5 α,6 β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.

KW - Carijoa

KW - Carijoside

KW - Cytotoxicity

KW - Elastase

KW - Glycoside

KW - Superoxide anion

UR - https://www.scopus.com/pages/publications/77955284769

U2 - 10.3390/md8072014

DO - 10.3390/md8072014

M3 - 文章

C2 - 20714421

AN - SCOPUS:77955284769

SN - 1660-3397

VL - 8

SP - 2014

EP - 2020

JO - Marine Drugs

JF - Marine Drugs

IS - 7

ER -

Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (clavulariidae)

Abstract

Keywords

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