TY - JOUR
T1 - CD169 + macrophages at the crossroads of antigen presentation
AU - Martinez-Pomares, Luisa
AU - Gordon, Siamon
PY - 2012/2
Y1 - 2012/2
N2 - CD169 + macrophages have fascinated immunologists because of their unique distribution in secondary lymphoid organs, redistribution upon immune activation and, lately, because of their contribution to antigen handling. Their association with B cell follicles prompted early studies on their involvement in B cell activation, and recent work has unveiled an unexpected role in facilitating activation of other lymphocyte subsets, such as invariant natural killer T (iNKT) cells. New data also argue that CD169 + macrophages activate CD8 T cells in response to dead cell-associated antigens in lymph nodes and by transferring antigen to dendritic cells (DCs) in the spleen. Understanding the role of CD169 + macrophages in the activation of acquired immunity could benefit the design of vaccination strategies, for example those aimed at eliciting cytotoxic T cells.
AB - CD169 + macrophages have fascinated immunologists because of their unique distribution in secondary lymphoid organs, redistribution upon immune activation and, lately, because of their contribution to antigen handling. Their association with B cell follicles prompted early studies on their involvement in B cell activation, and recent work has unveiled an unexpected role in facilitating activation of other lymphocyte subsets, such as invariant natural killer T (iNKT) cells. New data also argue that CD169 + macrophages activate CD8 T cells in response to dead cell-associated antigens in lymph nodes and by transferring antigen to dendritic cells (DCs) in the spleen. Understanding the role of CD169 + macrophages in the activation of acquired immunity could benefit the design of vaccination strategies, for example those aimed at eliciting cytotoxic T cells.
UR - http://www.scopus.com/inward/record.url?scp=84856510630&partnerID=8YFLogxK
U2 - 10.1016/j.it.2011.11.001
DO - 10.1016/j.it.2011.11.001
M3 - 文献综述
C2 - 22192781
AN - SCOPUS:84856510630
SN - 1471-4906
VL - 33
SP - 66
EP - 70
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -