CD169 + macrophages at the crossroads of antigen presentation

Luisa Martinez-Pomares*, Siamon Gordon

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

157 Scopus citations

Abstract

CD169 + macrophages have fascinated immunologists because of their unique distribution in secondary lymphoid organs, redistribution upon immune activation and, lately, because of their contribution to antigen handling. Their association with B cell follicles prompted early studies on their involvement in B cell activation, and recent work has unveiled an unexpected role in facilitating activation of other lymphocyte subsets, such as invariant natural killer T (iNKT) cells. New data also argue that CD169 + macrophages activate CD8 T cells in response to dead cell-associated antigens in lymph nodes and by transferring antigen to dendritic cells (DCs) in the spleen. Understanding the role of CD169 + macrophages in the activation of acquired immunity could benefit the design of vaccination strategies, for example those aimed at eliciting cytotoxic T cells.

Original languageEnglish
Pages (from-to)66-70
Number of pages5
JournalTrends in Immunology
Volume33
Issue number2
DOIs
StatePublished - 02 2012
Externally publishedYes

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