Ceftriaxone treatment for neuronal deficits: A histological and MEMRI study in a Rat model of dementia with Lewy bodies

Ying Jui Ho; Jun Cheng Weng; Chih Li Lin; Mei Shiuan Shen; Hsin Hua Li; Wen Chieh Liao; Nu Man Tsai; Ching Sui Hung; Te Jen Lai; I. Yen Lee

doi:10.1155/2018/4618716

Ceftriaxone treatment for neuronal deficits: A histological and MEMRI study in a Rat model of dementia with Lewy bodies

Ying Jui Ho^*, Jun Cheng Weng, Chih Li Lin, Mei Shiuan Shen, Hsin Hua Li, Wen Chieh Liao, Nu Man Tsai, Ching Sui Hung^*, Te Jen Lai^*, I. Yen Lee^*

^*Corresponding author for this work

Department of Medical Imaging and Radiological Sciences

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α-synuclein accumulation in the brain in a DLB rat model. The data showed that CEF corrected neuronal density and activity in the hippocampal CA1 area, suppressed hyperactivity in the subthalamic nucleus, and reduced α-synuclein accumulation, indicating that CEF is a potential agent in the treatment of DLB.

Original language	English
Article number	4618716
Journal	Behavioural Neurology
Volume	2018
DOIs	https://doi.org/10.1155/2018/4618716
State	Published - 2018

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Copyright © 2018 Ying-Jui Ho et al.

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title = "Ceftriaxone treatment for neuronal deficits: A histological and MEMRI study in a Rat model of dementia with Lewy bodies",

abstract = "Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α-synuclein accumulation in the brain in a DLB rat model. The data showed that CEF corrected neuronal density and activity in the hippocampal CA1 area, suppressed hyperactivity in the subthalamic nucleus, and reduced α-synuclein accumulation, indicating that CEF is a potential agent in the treatment of DLB.",

author = "Ho, {Ying Jui} and Weng, {Jun Cheng} and Lin, {Chih Li} and Shen, {Mei Shiuan} and Li, {Hsin Hua} and Liao, {Wen Chieh} and Tsai, {Nu Man} and Hung, {Ching Sui} and Lai, {Te Jen} and Lee, {I. Yen}",

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year = "2018",

doi = "10.1155/2018/4618716",

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volume = "2018",

journal = "Behavioural Neurology",

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T2 - A histological and MEMRI study in a Rat model of dementia with Lewy bodies

AU - Ho, Ying Jui

AU - Weng, Jun Cheng

AU - Lin, Chih Li

AU - Shen, Mei Shiuan

AU - Li, Hsin Hua

AU - Liao, Wen Chieh

AU - Tsai, Nu Man

AU - Hung, Ching Sui

AU - Lai, Te Jen

AU - Lee, I. Yen

PY - 2018

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N2 - Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α-synuclein accumulation in the brain in a DLB rat model. The data showed that CEF corrected neuronal density and activity in the hippocampal CA1 area, suppressed hyperactivity in the subthalamic nucleus, and reduced α-synuclein accumulation, indicating that CEF is a potential agent in the treatment of DLB.

AB - Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α-synuclein accumulation in the brain in a DLB rat model. The data showed that CEF corrected neuronal density and activity in the hippocampal CA1 area, suppressed hyperactivity in the subthalamic nucleus, and reduced α-synuclein accumulation, indicating that CEF is a potential agent in the treatment of DLB.

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Ceftriaxone treatment for neuronal deficits: A histological and MEMRI study in a Rat model of dementia with Lewy bodies

Abstract

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