@inproceedings{aefc7fb25c93410396a48cb853da4750,
title = "Cell type classification based on specific membrane capacitance and cytoplasm conductivity using microfluidic devices",
abstract = "This paper presents a microfluidic system enabling cell type classification based on continuous characterization of cellular specific membrane capacitance (Cspecific membrane) and cytoplasm conductivity (σ cytoplasm) In this study, cells were aspirated continuously through a constriction channel with cell elongations and two-frequency impedance profiles measured. Based on a distributed equivalent circuit model, raw data were translated into Cspecific membrane and σcytoplasm. Two lung cancer cell lines of CRL-5803 cells (ncell=489) and CCL-185 cells (ncell=487) were tested, producing C specific membrane of 1.63±0.52 μF/cm2 vs. 2.00±0.60 μF/cm2 (p<0.001) and σ cytoplasm of 0.90±0.19 S/m vs. 0.73±0.17 S/m (p<0.001), suggesting these two lung tumor cell lines can be classified based on electrical properties.",
keywords = "Cytoplasm conductivity, Distributed equivalent circuit model, High throughput, Microfluidics, Single-cell analysis, Specific membrane capacitance",
author = "Y. Zhao and D. Chen and Y. Luo and S. Huang and H. Lee and M. Wu and R. Long and J. Wang and J. Chen",
year = "2013",
language = "英语",
isbn = "9781632666246",
series = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
publisher = "Chemical and Biological Microsystems Society",
pages = "856--858",
booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",
}