Abstract
Atopic dermatitis (AD) is a highly pruritic, chronic, and relapsing inflammatory skin disease. Recent interest in AD has been sparked by reports of its increasing prevalence and its contribution to increasing health care costs. A precise understanding of immunologic mechanisms is crucial for the development of effective treatment strategies for AD. Various studies reveal that AD has a multifactorial cause with the activation of complex immunologic and inflammatory pathways. This review will discuss cellular-mediated immunological pathomechanisms of AD. Emphasis will be given to the role played by T cells, antigen-presenting cells, eosinophils, and keratinocytes. We also examine the immunological effect of superantigens on various inflammatory cells including T regulatory cells.
| Original language | English |
|---|---|
| Pages (from-to) | 191-198 |
| Number of pages | 8 |
| Journal | Clinical Reviews in Allergy and Immunology |
| Volume | 33 |
| Issue number | 3 |
| DOIs | |
| State | Published - 12 2007 |
Keywords
- Antigen-presenting cell
- Atopic dermatitis
- Eosinophil
- Keratinocyte
- Superantigens
- T cell
- T regulatory cell