Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)

Yao Tsung Yeh; Sung Chun Lin; Gene Hsiang Lee; Zhi Hong Wen; Tsong Long Hwang; Yu Jen Wu; Jih Jung Chen; Lee Shing Fang; Mei Kang Yuan; Ping Jyun Sung

doi:10.3390/MD19030130

Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)

Yao Tsung Yeh, Sung Chun Lin, Gene Hsiang Lee, Zhi Hong Wen, Tsong Long Hwang, Yu Jen Wu, Jih Jung Chen, Lee Shing Fang, Mei Kang Yuan^*, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.

Original language	English
Article number	130
Journal	Marine Drugs
Volume	19
Issue number	3
DOIs	https://doi.org/10.3390/MD19030130
State	Published - 03 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Lobophytum crassum
X-ray
anti-inflammation
cembranoid
iNOS
lobocrassin
lobohedleolide

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10.3390/MD19030130

Cite this

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title = "Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)",

abstract = "Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.",

keywords = "Lobophytum crassum, X-ray, anti-inflammation, cembranoid, iNOS, lobocrassin, lobohedleolide",

author = "Yeh, \{Yao Tsung\} and Lin, \{Sung Chun\} and Lee, \{Gene Hsiang\} and Wen, \{Zhi Hong\} and Hwang, \{Tsong Long\} and Wu, \{Yu Jen\} and Chen, \{Jih Jung\} and Fang, \{Lee Shing\} and Yuan, \{Mei Kang\} and Sung, \{Ping Jyun\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = mar,

doi = "10.3390/MD19030130",

language = "英语",

volume = "19",

journal = "Marine Drugs",

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AU - Yeh, Yao Tsung

AU - Lin, Sung Chun

AU - Lee, Gene Hsiang

AU - Wen, Zhi Hong

AU - Hwang, Tsong Long

AU - Wu, Yu Jen

AU - Chen, Jih Jung

AU - Fang, Lee Shing

AU - Yuan, Mei Kang

AU - Sung, Ping Jyun

PY - 2021/3

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N2 - Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.

AB - Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.

KW - Lobophytum crassum

KW - X-ray

KW - anti-inflammation

KW - cembranoid

KW - iNOS

KW - lobocrassin

KW - lobohedleolide

UR - https://www.scopus.com/pages/publications/85102606782

U2 - 10.3390/MD19030130

DO - 10.3390/MD19030130

M3 - 文章

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AN - SCOPUS:85102606782

SN - 1660-3397

VL - 19

JO - Marine Drugs

JF - Marine Drugs

IS - 3

M1 - 130

ER -

Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)

Abstract

Bibliographical note

Keywords

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