Central nervous system infections in patients with systemic lupus erythematosus

Jeng Juh Hung, Liang Shiou Ou, Wen I. Lee, Jing Long Huang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations

Abstract

Objective. To evaluate the clinical profiles of patients with systemic lupus erythematosus (SLE) with central nervous system (CNS) infections. Method. We retrospectively reviewed patients with SLE with CNS infections from January 1983 to June 2003. The clinical features, laboratory data, and prognoses of these patients were recorded. Results. During the 20-year review period, 17 SLE patients with CNS infections were identified. The mean age at CNS infection was 29.6 ± 15.3 years. Cryptococcal infection was identified in 10 patients and bacterial meningitis in 7. Most patients (94%) had active SLE at the time of CNS infection. Fifteen patients received corticosteroid therapy and of these, 7 received it in conjunction with immunosuppressive agents. The most common presentation was headache, fever, and vomiting. The mortality rate among the 17 patients was high (41.2%). Conclusion. Cryptococcal meningitis played the major role in CNS infection of patients with SLE, and it cannot be ruled out even when the cerebrospinal fluid (CSF) white blood cell count is within normal range. CSF India ink and latex agglutination testing for Cryptococcal antigen should be performed and are effective screening tools to establish an early diagnosis.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalJournal of Rheumatology
Volume32
Issue number1
StatePublished - 01 2005

Keywords

  • Brain abscess
  • Cryptococcus
  • Listeria
  • Meningitis
  • Systemic lupus erythematosus

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