Cerebrospinal fluid electrolytes and acid-base in diabetic patients

Chia Chih Liao, Te Hsin Hou, Huang Ping Yu, Allen Li, Fu Chao Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations


Background: Diabetes mellitus (DM) has detrimental effects on the function of microvascular beds, resulting in blood-brain barrier (BBB) dysfunction. The objective of the study was to investigate whether DM affects the brain physiology through composition of cerebrospinal fluid (CSF) and compare gas tension and electrolyte levels in CSF between the diabetic and nondiabetic populations. Methods: Patients aged between 20 and 70 years scheduled for elective orthopedic or urologic surgery requiring spinal anesthesia were enrolled. They were assigned to either of the two groups (control or type 2 DM). Gas tension and electrolytes in the CSF and whole blood samples were measured in both groups. Results: All 49 enrolled patients (24 in the control and 25 in the DM group) completed the study. The concentrations of Na+ and Mg2+ in the blood were significantly lower in the DM group than those in the control. The levels of pCO2 and HCO3- in the CSF were lower in the DM group than in the control group. In addition, there was a marked increase in the glucose level in both the blood and CSF in the DM group. Conclusion: The results show that there were some homeostatic changes in blood and CSF in patients with DM.

Original languageEnglish
Pages (from-to)448-455
Number of pages8
JournalTranslational Neuroscience
Issue number1
StatePublished - 01 01 2021

Bibliographical note

Publisher Copyright:
© 2021 Chia-Chih Liao et al., published by De Gruyter.


  • acid-base
  • cerebrospinal fluid
  • diabetes mellitus
  • electrolyte


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