Change of cardiac β-adrenoceptors in lead-exposed rats

Huoy Rou Chang*, Shun Sheng Chen, Der An Tsao, Juei Tang Cheng, Chi Kung Ho, Hsin Su Yu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations


The effect of lead on cardiac β-adrenoceptors was studied. Wistar rats used in these trials were divided into seven groups of ten animals each (A-G). Of these, groups B was given drinking water containing 0.01% lead acetate, group C 0.05%, group D 0.1%, group E 0.5%, group F 1% and group G 2% for a period of 60 days. Group A was given pure water. A radioligand-binding assay fulfilling strict criteria of receptor affinity and density was used to quantify cardiac β-adrenoceptors. Application of a trend test indicated that both blood and heart lead levels increased significantly from group A to group G (A < G), but that β-adrenoceptor density decreased (G < A), whereas K(d) did not vary among the seven groups. Linear regression analysis showed that decrease of cardiac β-adrenergic receptor density was closely related to elevation of blood and heart lead levels. The results show that lead exposure results in a reduction of cardiac β-adrenoceptor density.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
Issue number1-2
StatePublished - 21 11 1997
Externally publishedYes


  • Blood lead level
  • Heart lead level
  • Lead
  • β-Adrenoceptors


Dive into the research topics of 'Change of cardiac β-adrenoceptors in lead-exposed rats'. Together they form a unique fingerprint.

Cite this