Changes in high-density lipoprotein and homeostasis model assessment of insulin resistance in medicated schizophrenic patients and healthy controls

Meng Chang Tsai, Chia Ming Chang, Tiao Lai Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Background: This study intended to simultaneously investigate the relationships between high-density lipoprotein (HDL) and homeostasis model assessment of insulin resistance (HOMA-IR) in medicated schizophrenic patients vs healthy controls. Methods: During a 1-year period, we recruited 37 medicated schizophrenic patients and 30 healthy controls. Metabolic syndrome-related biomarkers including insulin and lipid profiles were enzymatically determined. Results: An analysis of covariance (ANCOVA) with BMI adjustment revealed that the patients had significantly lower HDL levels than the healthy controls (p = 0.017). ANCOVA with age adjustment revealed that the patients had significantly higher fasting insulin levels than the healthy controls (p = 0.034). In addition, in comparison with the healthy controls, the patients had higher mean serum levels of triglycerides, low-density lipoprotein, and total cholesterol as well as higher HOMA-IR values. However, there were no significant differences in any marker in the ANCOVA analysis after adjustment for age or BMI. Conclusion: We found lower HDL and higher insulin levels in medicated schizophrenic patients than in healthy controls.

Original languageEnglish
Pages (from-to)613-618
Number of pages6
JournalChang Gung Medical Journal
Volume33
Issue number6
StatePublished - 11 2010

Keywords

  • HOMA-IR
  • High-density lipoprotein (HDL)
  • Insulin
  • Schizophrenia

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