Abstract
Background: This study intended to simultaneously investigate the relationships between high-density lipoprotein (HDL) and homeostasis model assessment of insulin resistance (HOMA-IR) in medicated schizophrenic patients vs healthy controls. Methods: During a 1-year period, we recruited 37 medicated schizophrenic patients and 30 healthy controls. Metabolic syndrome-related biomarkers including insulin and lipid profiles were enzymatically determined. Results: An analysis of covariance (ANCOVA) with BMI adjustment revealed that the patients had significantly lower HDL levels than the healthy controls (p = 0.017). ANCOVA with age adjustment revealed that the patients had significantly higher fasting insulin levels than the healthy controls (p = 0.034). In addition, in comparison with the healthy controls, the patients had higher mean serum levels of triglycerides, low-density lipoprotein, and total cholesterol as well as higher HOMA-IR values. However, there were no significant differences in any marker in the ANCOVA analysis after adjustment for age or BMI. Conclusion: We found lower HDL and higher insulin levels in medicated schizophrenic patients than in healthy controls.
Original language | English |
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Pages (from-to) | 613-618 |
Number of pages | 6 |
Journal | Chang Gung Medical Journal |
Volume | 33 |
Issue number | 6 |
State | Published - 11 2010 |
Keywords
- HOMA-IR
- High-density lipoprotein (HDL)
- Insulin
- Schizophrenia