Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men.

CS Tsai; KY Lin; BH Liou; CS Chiou; YC Lin; YT Lee; CJ Yang; HJ Tang; YS Liao; CE Liu; Chih-Hung Lee; PL Lu; SH Huang; CC Hung; WC Ko

doi:10.1080/22221751.2022.2031309

Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men.

CS Tsai, KY Lin, BH Liou, CS Chiou, YC Lin, YT Lee, CJ Yang, HJ Tang, YS Liao, CE Liu, Chih-Hung Lee, PL Lu, SH Huang, CC Hung, WC Ko

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

8 Scopus citations

Abstract

Shigellosis appears to increase in certain at-risk populations in developed countries. Based on the nationwide surveillance, the annual incidence of shigellosis in Taiwan (1999-2019) was 0.38-5.77 cases per 100,000 people. Indigenous shigellosis has mostly affected men who have sex with men (MSM) and people living with HIV (PLWH) since 2015. In this retrospective study, compared with those diagnosed before 2015, indigenous cases diagnosed during 2015-2019 mostly occurred in male adults (96.0% vs 47.1%, < 0.001), with a longer hospital stay (median 5.0 vs 3.5 days, = 0.029) and different coinfections. The predominant strains in 2015 and 2016 were ciprofloxacin-resistant and azithromycin non-susceptible 3a, which had been replaced by ciprofloxacin-resistant 2a since 2018. Notably, six indigenous cases were caused by cefotaxime-resistant . Inappropriate use of empiric antibiotic treatment was common. In conclusion, there is an ongoing spread of ciprofloxacin-resistant shigellosis among PLWH and MSM and cefotaxime-resistant is an emerging threat in Taiwan.

Original language	American English
Pages (from-to)	1-30
Journal	Emerging microbes & infections
Volume	11
Issue number	1
DOIs	https://doi.org/10.1080/22221751.2022.2031309
State	Published - 2022

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10.1080/22221751.2022.2031309

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Tsai, CS., Lin, KY., Liou, BH., Chiou, CS., Lin, YC., Lee, YT., Yang, CJ., Tang, HJ., Liao, YS., Liu, CE., Lee, C.-H., Lu, PL., Huang, SH., Hung, CC., & Ko, WC. (2022). Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men. Emerging microbes & infections, 11(1), 1-30. https://doi.org/10.1080/22221751.2022.2031309

@article{cb24dff485b44b9f9fb52d2d48f328b3,

title = "Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men.",

abstract = "Shigellosis appears to increase in certain at-risk populations in developed countries. Based on the nationwide surveillance, the annual incidence of shigellosis in Taiwan (1999-2019) was 0.38-5.77 cases per 100,000 people. Indigenous shigellosis has mostly affected men who have sex with men (MSM) and people living with HIV (PLWH) since 2015. In this retrospective study, compared with those diagnosed before 2015, indigenous cases diagnosed during 2015-2019 mostly occurred in male adults (96.0\% vs 47.1\%, < 0.001), with a longer hospital stay (median 5.0 vs 3.5 days, = 0.029) and different coinfections. The predominant strains in 2015 and 2016 were ciprofloxacin-resistant and azithromycin non-susceptible 3a, which had been replaced by ciprofloxacin-resistant 2a since 2018. Notably, six indigenous cases were caused by cefotaxime-resistant . Inappropriate use of empiric antibiotic treatment was common. In conclusion, there is an ongoing spread of ciprofloxacin-resistant shigellosis among PLWH and MSM and cefotaxime-resistant is an emerging threat in Taiwan.",

author = "CS Tsai and KY Lin and BH Liou and CS Chiou and YC Lin and YT Lee and CJ Yang and HJ Tang and YS Liao and CE Liu and Chih-Hung Lee and PL Lu and SH Huang and CC Hung and WC Ko",

year = "2022",

doi = "10.1080/22221751.2022.2031309",

language = "American English",

volume = "11",

pages = "1--30",

journal = "Emerging microbes \& infections",

issn = "2222-1751",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

Tsai, CS, Lin, KY, Liou, BH, Chiou, CS, Lin, YC, Lee, YT, Yang, CJ, Tang, HJ, Liao, YS, Liu, CE, Lee, C-H, Lu, PL, Huang, SH, Hung, CC & Ko, WC 2022, 'Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men.', Emerging microbes & infections, vol. 11, no. 1, pp. 1-30. https://doi.org/10.1080/22221751.2022.2031309

TY - JOUR

T1 - Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men.

AU - Tsai, CS

AU - Lin, KY

AU - Liou, BH

AU - Chiou, CS

AU - Lin, YC

AU - Lee, YT

AU - Yang, CJ

AU - Tang, HJ

AU - Liao, YS

AU - Liu, CE

AU - Lee, Chih-Hung

AU - Lu, PL

AU - Huang, SH

AU - Hung, CC

AU - Ko, WC

PY - 2022

Y1 - 2022

N2 - Shigellosis appears to increase in certain at-risk populations in developed countries. Based on the nationwide surveillance, the annual incidence of shigellosis in Taiwan (1999-2019) was 0.38-5.77 cases per 100,000 people. Indigenous shigellosis has mostly affected men who have sex with men (MSM) and people living with HIV (PLWH) since 2015. In this retrospective study, compared with those diagnosed before 2015, indigenous cases diagnosed during 2015-2019 mostly occurred in male adults (96.0% vs 47.1%, < 0.001), with a longer hospital stay (median 5.0 vs 3.5 days, = 0.029) and different coinfections. The predominant strains in 2015 and 2016 were ciprofloxacin-resistant and azithromycin non-susceptible 3a, which had been replaced by ciprofloxacin-resistant 2a since 2018. Notably, six indigenous cases were caused by cefotaxime-resistant . Inappropriate use of empiric antibiotic treatment was common. In conclusion, there is an ongoing spread of ciprofloxacin-resistant shigellosis among PLWH and MSM and cefotaxime-resistant is an emerging threat in Taiwan.

AB - Shigellosis appears to increase in certain at-risk populations in developed countries. Based on the nationwide surveillance, the annual incidence of shigellosis in Taiwan (1999-2019) was 0.38-5.77 cases per 100,000 people. Indigenous shigellosis has mostly affected men who have sex with men (MSM) and people living with HIV (PLWH) since 2015. In this retrospective study, compared with those diagnosed before 2015, indigenous cases diagnosed during 2015-2019 mostly occurred in male adults (96.0% vs 47.1%, < 0.001), with a longer hospital stay (median 5.0 vs 3.5 days, = 0.029) and different coinfections. The predominant strains in 2015 and 2016 were ciprofloxacin-resistant and azithromycin non-susceptible 3a, which had been replaced by ciprofloxacin-resistant 2a since 2018. Notably, six indigenous cases were caused by cefotaxime-resistant . Inappropriate use of empiric antibiotic treatment was common. In conclusion, there is an ongoing spread of ciprofloxacin-resistant shigellosis among PLWH and MSM and cefotaxime-resistant is an emerging threat in Taiwan.

U2 - 10.1080/22221751.2022.2031309

DO - 10.1080/22221751.2022.2031309

M3 - Journal Article

C2 - 35045788

SN - 2222-1751

VL - 11

SP - 1

EP - 30

JO - Emerging microbes & infections

JF - Emerging microbes & infections

IS - 1

ER -

Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men.

Abstract

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