Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection

Shu Hsien Lin; Hock Liew Eng; Yueh Wei Liu; Chih Che Lin; Chee Chien Yong; Chih Chi Wang; Chao Long Chen; Fang Ying Kuo; Yu Fan Cheng; Jing Houng Wang; Yi Hao Yen; Ting Ting Liu; Wei Feng Li; Chien Hung Chen

doi:10.1016/j.amjsurg.2021.03.065

Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection

Shu Hsien Lin, Hock Liew Eng, Yueh Wei Liu, Chih Che Lin, Chee Chien Yong, Chih Chi Wang, Chao Long Chen, Fang Ying Kuo^*, Yu Fan Cheng, Jing Houng Wang, Yi Hao Yen^*, Ting Ting Liu, Wei Feng Li, Chien Hung Chen

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

Background: Large well-differentiated hepatocellular carcinoma (HCC) ≥ 3 cm (defined as atypical HCC) is uncommon. We evaluated the characteristics and outcomes of atypical HCC patients underwent liver resection (LR). Methods: This retrospective study enrolled patients who underwent LR for HCC from 2007 to 2017. Patient characteristics and overall survival (OS) were compared between patients with atypical HCC and patients with typical HCC (moderate-to-undifferentiated HCC ≥ 3 cm). Results: Among 598 patients, 51 (8.5%) had atypical HCC. Patients with atypical HCC had higher rates of non-hepatitis B or C infections (p = 0.02) and American Joint Committee on Cancer T1 pathology (p < 0.001), a lower rate of alpha-fetoprotein >20 ng/ml (p < 0.001) and a longer OS (p < 0.001) than those with typical HCC. Multivariate analysis showed that atypical HCC was associated with OS (HR = 0.50, 95% CI = 0.27–0.91, p = 0.02). Conclusions: Patients with atypical HCC have a higher rate of non-hepatitis B or C infections and a lower rate of aggressive tumor biologic behavior. Atypical HCC is an independent predictor of OS.

Original language	English
Pages (from-to)	339-345
Number of pages	7
Journal	American Journal of Surgery
Volume	223
Issue number	2
DOIs	https://doi.org/10.1016/j.amjsurg.2021.03.065
State	Published - 02 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

Keywords

Hepatocellular carcinoma
Liver resection
Tumor differentiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.amjsurg.2021.03.065

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Lin, S. H., Eng, H. L., Liu, Y. W., Lin, C. C., Yong, C. C., Wang, C. C., Chen, C. L., Kuo, F. Y., Cheng, Y. F., Wang, J. H., Yen, Y. H., Liu, T. T., Li, W. F., & Chen, C. H. (2022). Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection. American Journal of Surgery, 223(2), 339-345. https://doi.org/10.1016/j.amjsurg.2021.03.065

@article{51e690683ab14496a6455011ccd6bd69,

title = "Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection",

abstract = "Background: Large well-differentiated hepatocellular carcinoma (HCC) ≥ 3 cm (defined as atypical HCC) is uncommon. We evaluated the characteristics and outcomes of atypical HCC patients underwent liver resection (LR). Methods: This retrospective study enrolled patients who underwent LR for HCC from 2007 to 2017. Patient characteristics and overall survival (OS) were compared between patients with atypical HCC and patients with typical HCC (moderate-to-undifferentiated HCC ≥ 3 cm). Results: Among 598 patients, 51 (8.5\%) had atypical HCC. Patients with atypical HCC had higher rates of non-hepatitis B or C infections (p = 0.02) and American Joint Committee on Cancer T1 pathology (p < 0.001), a lower rate of alpha-fetoprotein >20 ng/ml (p < 0.001) and a longer OS (p < 0.001) than those with typical HCC. Multivariate analysis showed that atypical HCC was associated with OS (HR = 0.50, 95\% CI = 0.27–0.91, p = 0.02). Conclusions: Patients with atypical HCC have a higher rate of non-hepatitis B or C infections and a lower rate of aggressive tumor biologic behavior. Atypical HCC is an independent predictor of OS.",

keywords = "Hepatocellular carcinoma, Liver resection, Tumor differentiation",

author = "Lin, \{Shu Hsien\} and Eng, \{Hock Liew\} and Liu, \{Yueh Wei\} and Lin, \{Chih Che\} and Yong, \{Chee Chien\} and Wang, \{Chih Chi\} and Chen, \{Chao Long\} and Kuo, \{Fang Ying\} and Cheng, \{Yu Fan\} and Wang, \{Jing Houng\} and Yen, \{Yi Hao\} and Liu, \{Ting Ting\} and Li, \{Wei Feng\} and Chen, \{Chien Hung\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2022",

month = feb,

doi = "10.1016/j.amjsurg.2021.03.065",

language = "英语",

volume = "223",

pages = "339--345",

journal = "American Journal of Surgery",

issn = "0002-9610",

publisher = "Elsevier Inc.",

number = "2",

}

Lin, SH, Eng, HL, Liu, YW, Lin, CC, Yong, CC, Wang, CC, Chen, CL, Kuo, FY, Cheng, YF, Wang, JH, Yen, YH, Liu, TT, Li, WF & Chen, CH 2022, 'Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection', American Journal of Surgery, vol. 223, no. 2, pp. 339-345. https://doi.org/10.1016/j.amjsurg.2021.03.065

TY - JOUR

T1 - Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection

AU - Lin, Shu Hsien

AU - Eng, Hock Liew

AU - Liu, Yueh Wei

AU - Lin, Chih Che

AU - Yong, Chee Chien

AU - Wang, Chih Chi

AU - Chen, Chao Long

AU - Kuo, Fang Ying

AU - Cheng, Yu Fan

AU - Wang, Jing Houng

AU - Yen, Yi Hao

AU - Liu, Ting Ting

AU - Li, Wei Feng

AU - Chen, Chien Hung

PY - 2022/2

Y1 - 2022/2

N2 - Background: Large well-differentiated hepatocellular carcinoma (HCC) ≥ 3 cm (defined as atypical HCC) is uncommon. We evaluated the characteristics and outcomes of atypical HCC patients underwent liver resection (LR). Methods: This retrospective study enrolled patients who underwent LR for HCC from 2007 to 2017. Patient characteristics and overall survival (OS) were compared between patients with atypical HCC and patients with typical HCC (moderate-to-undifferentiated HCC ≥ 3 cm). Results: Among 598 patients, 51 (8.5%) had atypical HCC. Patients with atypical HCC had higher rates of non-hepatitis B or C infections (p = 0.02) and American Joint Committee on Cancer T1 pathology (p < 0.001), a lower rate of alpha-fetoprotein >20 ng/ml (p < 0.001) and a longer OS (p < 0.001) than those with typical HCC. Multivariate analysis showed that atypical HCC was associated with OS (HR = 0.50, 95% CI = 0.27–0.91, p = 0.02). Conclusions: Patients with atypical HCC have a higher rate of non-hepatitis B or C infections and a lower rate of aggressive tumor biologic behavior. Atypical HCC is an independent predictor of OS.

AB - Background: Large well-differentiated hepatocellular carcinoma (HCC) ≥ 3 cm (defined as atypical HCC) is uncommon. We evaluated the characteristics and outcomes of atypical HCC patients underwent liver resection (LR). Methods: This retrospective study enrolled patients who underwent LR for HCC from 2007 to 2017. Patient characteristics and overall survival (OS) were compared between patients with atypical HCC and patients with typical HCC (moderate-to-undifferentiated HCC ≥ 3 cm). Results: Among 598 patients, 51 (8.5%) had atypical HCC. Patients with atypical HCC had higher rates of non-hepatitis B or C infections (p = 0.02) and American Joint Committee on Cancer T1 pathology (p < 0.001), a lower rate of alpha-fetoprotein >20 ng/ml (p < 0.001) and a longer OS (p < 0.001) than those with typical HCC. Multivariate analysis showed that atypical HCC was associated with OS (HR = 0.50, 95% CI = 0.27–0.91, p = 0.02). Conclusions: Patients with atypical HCC have a higher rate of non-hepatitis B or C infections and a lower rate of aggressive tumor biologic behavior. Atypical HCC is an independent predictor of OS.

KW - Hepatocellular carcinoma

KW - Liver resection

KW - Tumor differentiation

UR - https://www.scopus.com/pages/publications/85104066614

U2 - 10.1016/j.amjsurg.2021.03.065

DO - 10.1016/j.amjsurg.2021.03.065

M3 - 文章

C2 - 33840448

AN - SCOPUS:85104066614

SN - 0002-9610

VL - 223

SP - 339

EP - 345

JO - American Journal of Surgery

JF - American Journal of Surgery

IS - 2

ER -

Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection

Abstract

Bibliographical note

Keywords

UN SDGs

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