Characteristics of isolated sphenoid sinus aspergilloma: Report of twelve cases and literature review

Objectives: Isolated sphenoid sinus aspergilloma (ISSA) is a form of fungal sinus infection that is distinct from allergic fungal sinusitis, invasive fungal disease, and Aspergillus granulomas. In this study, we identify the characteristics of patients with ISSA to achieve timelier intervention for this easily neglected disease. Methods: In a retrospective study of patients with ISSA in our institution (1995 to 2006), 12 were identified. Results: Sixty-seven percent of our patients were more than 50 years of age, and a female preponderance was noted. Headache and postnasal drip were the two most common symptoms, and the samples from 78% of our patients with postnasal drip were blood-tinged. Computed tomographic scanning provided a sensitivity of 64% whereas endoscopic examination failed to identify abnormalities in any patients. Conclusions: Four characteristics were identified in the diagnosis of ISSA: female; usually above 50 years of age; with postnasal drip (especially blood-tinged); and headache (particularly periorbital or retro-orbital).