Characteristics of pre-S2 region of hepatitis B virus

Szecheng J. Lo; Ming Lii Chen; Mei Ling Chien; Yan Hwa Wu Lee

doi:10.1016/0006-291X(86)90006-9

Characteristics of pre-S2 region of hepatitis B virus

Szecheng J. Lo^*, Ming Lii Chen, Mei Ling Chien, Yan Hwa Wu Lee

^*Corresponding author for this work

National Yang Ming Chiao Tung University

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: 1) there are 20 amino acid substitutions, 2) the longest conserved amino acid sequence is located between amino acids 23 to 34, and 3) the 54th amino acid is identical within the same subtype but varies in different subtypes.

Original language	English
Pages (from-to)	382-388
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	135
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(86)90006-9
State	Published - 13 03 1986
Externally published	Yes

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title = "Characteristics of pre-S2 region of hepatitis B virus",

abstract = "The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: 1) there are 20 amino acid substitutions, 2) the longest conserved amino acid sequence is located between amino acids 23 to 34, and 3) the 54th amino acid is identical within the same subtype but varies in different subtypes.",

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year = "1986",

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doi = "10.1016/0006-291X(86)90006-9",

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TY - JOUR

T1 - Characteristics of pre-S2 region of hepatitis B virus

AU - Lo, Szecheng J.

AU - Chen, Ming Lii

AU - Chien, Mei Ling

AU - Lee, Yan Hwa Wu

PY - 1986/3/13

Y1 - 1986/3/13

N2 - The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: 1) there are 20 amino acid substitutions, 2) the longest conserved amino acid sequence is located between amino acids 23 to 34, and 3) the 54th amino acid is identical within the same subtype but varies in different subtypes.

AB - The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: 1) there are 20 amino acid substitutions, 2) the longest conserved amino acid sequence is located between amino acids 23 to 34, and 3) the 54th amino acid is identical within the same subtype but varies in different subtypes.

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U2 - 10.1016/0006-291X(86)90006-9

DO - 10.1016/0006-291X(86)90006-9

M3 - 文章

C2 - 3754440

AN - SCOPUS:0022498288

SN - 0006-291X

VL - 135

SP - 382

EP - 388

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Characteristics of pre-S2 region of hepatitis B virus

Abstract

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