Characteristics of the X gene of hepatitis B virus

Szecheng J. Lo; Mei Ling Chien; Yan Hwa Wu Lee

doi:10.1016/0042-6822(88)90081-5

Characteristics of the X gene of hepatitis B virus

Szecheng J. Lo^*
, Mei Ling Chien
, Yan Hwa Wu Lee

^*Corresponding author for this work

National Yang Ming Chiao Tung University

Research output: Contribution to journal › Journal Article › peer-review

31 Scopus citations

Abstract

The 465-nucleotide sequence of the X gene from our cloned hepatitis B virus (HBV) DNA (subtype adw) was determined and compared to the same gene of 10 other published HBV sequences (3 of adw, 4 of adr, 2 of ayw, and 1 of ayr). We found (1) a total of 56 base differences among the 11 sequences (without counting the 27-base deletion in one adr) which resulted in 88% nucleotide homology, and (ii) 5 pairs of repeated sequence (3 direct repeats and 2 inverted repeats) that were highly conserved. Comparison of the protein amino acid sequences indicated that (i) there is 80% amino acid homology in total, and (ii) there are four highly conserved cysteine residues. In addition, the X gene of the adw subtype is more conserved than that of adr.

Original language	English
Pages (from-to)	289-292
Number of pages	4
Journal	Virology
Volume	167
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(88)90081-5
State	Published - 11 1988
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1016/0042-6822(88)90081-5

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title = "Characteristics of the X gene of hepatitis B virus",

abstract = "The 465-nucleotide sequence of the X gene from our cloned hepatitis B virus (HBV) DNA (subtype adw) was determined and compared to the same gene of 10 other published HBV sequences (3 of adw, 4 of adr, 2 of ayw, and 1 of ayr). We found (1) a total of 56 base differences among the 11 sequences (without counting the 27-base deletion in one adr) which resulted in 88\% nucleotide homology, and (ii) 5 pairs of repeated sequence (3 direct repeats and 2 inverted repeats) that were highly conserved. Comparison of the protein amino acid sequences indicated that (i) there is 80\% amino acid homology in total, and (ii) there are four highly conserved cysteine residues. In addition, the X gene of the adw subtype is more conserved than that of adr.",

author = "Lo, \{Szecheng J.\} and Chien, \{Mei Ling\} and Lee, \{Yan Hwa Wu\}",

year = "1988",

month = nov,

doi = "10.1016/0042-6822(88)90081-5",

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T1 - Characteristics of the X gene of hepatitis B virus

AU - Lo, Szecheng J.

AU - Chien, Mei Ling

AU - Lee, Yan Hwa Wu

PY - 1988/11

Y1 - 1988/11

N2 - The 465-nucleotide sequence of the X gene from our cloned hepatitis B virus (HBV) DNA (subtype adw) was determined and compared to the same gene of 10 other published HBV sequences (3 of adw, 4 of adr, 2 of ayw, and 1 of ayr). We found (1) a total of 56 base differences among the 11 sequences (without counting the 27-base deletion in one adr) which resulted in 88% nucleotide homology, and (ii) 5 pairs of repeated sequence (3 direct repeats and 2 inverted repeats) that were highly conserved. Comparison of the protein amino acid sequences indicated that (i) there is 80% amino acid homology in total, and (ii) there are four highly conserved cysteine residues. In addition, the X gene of the adw subtype is more conserved than that of adr.

AB - The 465-nucleotide sequence of the X gene from our cloned hepatitis B virus (HBV) DNA (subtype adw) was determined and compared to the same gene of 10 other published HBV sequences (3 of adw, 4 of adr, 2 of ayw, and 1 of ayr). We found (1) a total of 56 base differences among the 11 sequences (without counting the 27-base deletion in one adr) which resulted in 88% nucleotide homology, and (ii) 5 pairs of repeated sequence (3 direct repeats and 2 inverted repeats) that were highly conserved. Comparison of the protein amino acid sequences indicated that (i) there is 80% amino acid homology in total, and (ii) there are four highly conserved cysteine residues. In addition, the X gene of the adw subtype is more conserved than that of adr.

UR - https://www.scopus.com/pages/publications/0023692313

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DO - 10.1016/0042-6822(88)90081-5

M3 - 文章

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AN - SCOPUS:0023692313

SN - 0042-6822

VL - 167

SP - 289

EP - 292

JO - Virology

JF - Virology

IS - 1

ER -

Characteristics of the X gene of hepatitis B virus

Abstract

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