Characterization of mdcR, a regulatory gene of the malonate catabolic system in Klebsiella pneumoniae

Hwei Ling Peng; Sheng Ru Shiou; Hwan You Chang

doi:10.1128/jb.181.7.2302-2306.1999

Characterization of mdcR, a regulatory gene of the malonate catabolic system in Klebsiella pneumoniae

Hwei Ling Peng
, Sheng Ru Shiou
, Hwan You Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

13 Scopus citations

Abstract

The Klebsiella pneumoniae mdcR gene, which encodes a LysR-type regulator, was overexpressed in Escherichia coli. Purified MdcR was found to bind specifically to the control region of either the malonate decarboxylase (mdc) genes or mdcR. We have also demonstrated that MdcR is an activator of the expression of the mdc genes, whereas it represses the transcription of the putative control region of mdcR, P(mdcR), indicating a negative autoregulatory control.

Original language	English
Pages (from-to)	2302-2306
Number of pages	5
Journal	Journal of Bacteriology
Volume	181
Issue number	7
DOIs	https://doi.org/10.1128/jb.181.7.2302-2306.1999
State	Published - 04 1999
Externally published	Yes

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10.1128/jb.181.7.2302-2306.1999

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title = "Characterization of mdcR, a regulatory gene of the malonate catabolic system in Klebsiella pneumoniae",

abstract = "The Klebsiella pneumoniae mdcR gene, which encodes a LysR-type regulator, was overexpressed in Escherichia coli. Purified MdcR was found to bind specifically to the control region of either the malonate decarboxylase (mdc) genes or mdcR. We have also demonstrated that MdcR is an activator of the expression of the mdc genes, whereas it represses the transcription of the putative control region of mdcR, P(mdcR), indicating a negative autoregulatory control.",

author = "Peng, \{Hwei Ling\} and Shiou, \{Sheng Ru\} and Chang, \{Hwan You\}",

year = "1999",

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AU - Peng, Hwei Ling

AU - Shiou, Sheng Ru

AU - Chang, Hwan You

PY - 1999/4

Y1 - 1999/4

N2 - The Klebsiella pneumoniae mdcR gene, which encodes a LysR-type regulator, was overexpressed in Escherichia coli. Purified MdcR was found to bind specifically to the control region of either the malonate decarboxylase (mdc) genes or mdcR. We have also demonstrated that MdcR is an activator of the expression of the mdc genes, whereas it represses the transcription of the putative control region of mdcR, P(mdcR), indicating a negative autoregulatory control.

AB - The Klebsiella pneumoniae mdcR gene, which encodes a LysR-type regulator, was overexpressed in Escherichia coli. Purified MdcR was found to bind specifically to the control region of either the malonate decarboxylase (mdc) genes or mdcR. We have also demonstrated that MdcR is an activator of the expression of the mdc genes, whereas it represses the transcription of the putative control region of mdcR, P(mdcR), indicating a negative autoregulatory control.

UR - https://www.scopus.com/pages/publications/0032936314

U2 - 10.1128/jb.181.7.2302-2306.1999

DO - 10.1128/jb.181.7.2302-2306.1999

M3 - 文章

C2 - 10094715

AN - SCOPUS:0032936314

SN - 0021-9193

VL - 181

SP - 2302

EP - 2306

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 7

ER -

Characterization of mdcR, a regulatory gene of the malonate catabolic system in Klebsiella pneumoniae

Abstract

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