Characterizing emerging canine H3 influenza viruses

Luis Martinez-Sobrido; Pilar Blanco-Lobo; Laura Rodriguez; Theresa Fitzgerald; Hanyuan Zhang; Phuong Nguyen; Christopher S. Anderson; Jeanne Holden-Wiltse; Sanjukta Bandyopadhyay; Aitor Nogales; Marta L. DeDiego; Brian R. Wasik; Benjamin L. Miller; Carole Henry; Patrick C. Wilson; Mark Y. Sangster; John J. Treanor; David J. Topham; Lauren Byrd-Leotis; David A. Steinhauer; Richard D. Cummings; Jasmina M. Luczo; Stephen M. Tompkins; Kaori Sakamoto; Cheryl A. Jones; John Steel; Anice C. Lowen; Shamika Danzy; Hui Tao; Ashley L. Fink; Sabra L. Klein; Nicholas Wohlgemuth; Katherine J. Fenstermacher; Farah el Najjar; Andrew Pekosz; Lauren Sauer; Mitra K. Lewis; Kathryn Shaw-Saliba; Richard E. Rothman; Zhen Ying Liu; Kuan Fu Chen; Colin R. Parrish; Ian E.H. Voorhees; Yoshihiro Kawaoka; Gabriele Neumann; Shiho Chiba; Shufang Fan; Masato Hatta; Huihui Kong; Gongxun Zhong; Guojun Wang; Melissa B. Uccellini; Adolfo García-Sastre; Daniel R. Perez; Lucas M. Ferreri; Sander Herfst; Mathilde Richard; Ron Fouchier; David Burke; David Pattinson; Derek J. Smith; Victoria Meliopoulos; Pamela Freiden; Brandi Livingston; Bridgett Sharp; Sean Cherry; Juan Carlos Dib; Guohua Yang; Charles J. Russell; Subrata Barman; Richard J. Webby; Scott Krauss; Angela Danner; Karlie Woodard; Malik Peiris; R. A.P.M. Perera; M. C.W. Chan; Elena A. Govorkova; Bindumadhav M. Marathe; Philippe N.Q. Pascua; Gavin Smith; Yao Tsun Li; Paul G. Thomas; Stacey Schultz-Cherry

doi:10.1371/journal.ppat.1008409

Characterizing emerging canine H3 influenza viruses

Luis Martinez-Sobrido, Pilar Blanco-Lobo, Laura Rodriguez, Theresa Fitzgerald, Hanyuan Zhang, Phuong Nguyen, Christopher S. Anderson, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Aitor Nogales, Marta L. DeDiego, Brian R. Wasik, Benjamin L. Miller, Carole Henry, Patrick C. Wilson, Mark Y. Sangster, John J. Treanor, David J. Topham, Lauren Byrd-Leotis, David A. SteinhauerRichard D. Cummings, Jasmina M. Luczo, Stephen M. Tompkins, Kaori Sakamoto, Cheryl A. Jones, John Steel, Anice C. Lowen, Shamika Danzy, Hui Tao, Ashley L. Fink, Sabra L. Klein, Nicholas Wohlgemuth, Katherine J. Fenstermacher, Farah el Najjar, Andrew Pekosz, Lauren Sauer, Mitra K. Lewis, Kathryn Shaw-Saliba, Richard E. Rothman, Zhen Ying Liu, Kuan Fu Chen, Colin R. Parrish, Ian E.H. Voorhees, Yoshihiro Kawaoka, Gabriele Neumann, Shiho Chiba, Shufang Fan, Masato Hatta, Huihui Kong, Gongxun Zhong, Guojun Wang, Melissa B. Uccellini, Adolfo García-Sastre, Daniel R. Perez, Lucas M. Ferreri, Sander Herfst, Mathilde Richard, Ron Fouchier, David Burke, David Pattinson, Derek J. Smith, Victoria Meliopoulos, Pamela Freiden, Brandi Livingston, Bridgett Sharp, Sean Cherry, Juan Carlos Dib, Guohua Yang, Charles J. Russell, Subrata Barman, Richard J. Webby, Scott Krauss, Angela Danner, Karlie Woodard, Malik Peiris, R. A.P.M. Perera, M. C.W. Chan, Elena A. Govorkova, Bindumadhav M. Marathe, Philippe N.Q. Pascua, Gavin Smith, Yao Tsun Li, Paul G. Thomas, Stacey Schultz-Cherry

Department of Artificial Intelligence

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.

Original language	English
Article number	e1008409
Journal	PLoS Pathogens
Volume	16
Issue number	4
DOIs	https://doi.org/10.1371/journal.ppat.1008409
State	Published - 04 2020

Bibliographical note

Publisher Copyright:
© 2020 Martinez-Sobrido et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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10.1371/journal.ppat.1008409

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Martinez-Sobrido, L., Blanco-Lobo, P., Rodriguez, L., Fitzgerald, T., Zhang, H., Nguyen, P., Anderson, C. S., Holden-Wiltse, J., Bandyopadhyay, S., Nogales, A., DeDiego, M. L., Wasik, B. R., Miller, B. L., Henry, C., Wilson, P. C., Sangster, M. Y., Treanor, J. J., Topham, D. J., Byrd-Leotis, L., ... Schultz-Cherry, S. (2020). Characterizing emerging canine H3 influenza viruses. PLoS Pathogens, 16(4), Article e1008409. https://doi.org/10.1371/journal.ppat.1008409

@article{33946fb32d60478484cf09aba614b6ea,

title = "Characterizing emerging canine H3 influenza viruses",

abstract = "The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.",

author = "Luis Martinez-Sobrido and Pilar Blanco-Lobo and Laura Rodriguez and Theresa Fitzgerald and Hanyuan Zhang and Phuong Nguyen and Anderson, {Christopher S.} and Jeanne Holden-Wiltse and Sanjukta Bandyopadhyay and Aitor Nogales and DeDiego, {Marta L.} and Wasik, {Brian R.} and Miller, {Benjamin L.} and Carole Henry and Wilson, {Patrick C.} and Sangster, {Mark Y.} and Treanor, {John J.} and Topham, {David J.} and Lauren Byrd-Leotis and Steinhauer, {David A.} and Cummings, {Richard D.} and Luczo, {Jasmina M.} and Tompkins, {Stephen M.} and Kaori Sakamoto and Jones, {Cheryl A.} and John Steel and Lowen, {Anice C.} and Shamika Danzy and Hui Tao and Fink, {Ashley L.} and Klein, {Sabra L.} and Nicholas Wohlgemuth and Fenstermacher, {Katherine J.} and {el Najjar}, Farah and Andrew Pekosz and Lauren Sauer and Lewis, {Mitra K.} and Kathryn Shaw-Saliba and Rothman, {Richard E.} and Liu, {Zhen Ying} and Chen, {Kuan Fu} and Parrish, {Colin R.} and Voorhees, {Ian E.H.} and Yoshihiro Kawaoka and Gabriele Neumann and Shiho Chiba and Shufang Fan and Masato Hatta and Huihui Kong and Gongxun Zhong and Guojun Wang and Uccellini, {Melissa B.} and Adolfo Garc{\'i}a-Sastre and Perez, {Daniel R.} and Ferreri, {Lucas M.} and Sander Herfst and Mathilde Richard and Ron Fouchier and David Burke and David Pattinson and Smith, {Derek J.} and Victoria Meliopoulos and Pamela Freiden and Brandi Livingston and Bridgett Sharp and Sean Cherry and Dib, {Juan Carlos} and Guohua Yang and Russell, {Charles J.} and Subrata Barman and Webby, {Richard J.} and Scott Krauss and Angela Danner and Karlie Woodard and Malik Peiris and Perera, {R. A.P.M.} and Chan, {M. C.W.} and Govorkova, {Elena A.} and Marathe, {Bindumadhav M.} and Pascua, {Philippe N.Q.} and Gavin Smith and Li, {Yao Tsun} and Thomas, {Paul G.} and Stacey Schultz-Cherry",

note = "Publisher Copyright: {\textcopyright} 2020 Martinez-Sobrido et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2020",

month = apr,

doi = "10.1371/journal.ppat.1008409",

language = "英语",

volume = "16",

journal = "PLoS Pathogens",

issn = "1553-7366",

publisher = "Public Library of Science",

number = "4",

}

Martinez-Sobrido, L, Blanco-Lobo, P, Rodriguez, L, Fitzgerald, T, Zhang, H, Nguyen, P, Anderson, CS, Holden-Wiltse, J, Bandyopadhyay, S, Nogales, A, DeDiego, ML, Wasik, BR, Miller, BL, Henry, C, Wilson, PC, Sangster, MY, Treanor, JJ, Topham, DJ, Byrd-Leotis, L, Steinhauer, DA, Cummings, RD, Luczo, JM, Tompkins, SM, Sakamoto, K, Jones, CA, Steel, J, Lowen, AC, Danzy, S, Tao, H, Fink, AL, Klein, SL, Wohlgemuth, N, Fenstermacher, KJ, el Najjar, F, Pekosz, A, Sauer, L, Lewis, MK, Shaw-Saliba, K, Rothman, RE, Liu, ZY, Chen, KF, Parrish, CR, Voorhees, IEH, Kawaoka, Y, Neumann, G, Chiba, S, Fan, S, Hatta, M, Kong, H, Zhong, G, Wang, G, Uccellini, MB, García-Sastre, A, Perez, DR, Ferreri, LM, Herfst, S, Richard, M, Fouchier, R, Burke, D, Pattinson, D, Smith, DJ, Meliopoulos, V, Freiden, P, Livingston, B, Sharp, B, Cherry, S, Dib, JC, Yang, G, Russell, CJ, Barman, S, Webby, RJ, Krauss, S, Danner, A, Woodard, K, Peiris, M, Perera, RAPM, Chan, MCW, Govorkova, EA, Marathe, BM, Pascua, PNQ, Smith, G, Li, YT, Thomas, PG & Schultz-Cherry, S 2020, 'Characterizing emerging canine H3 influenza viruses', PLoS Pathogens, vol. 16, no. 4, e1008409. https://doi.org/10.1371/journal.ppat.1008409

TY - JOUR

T1 - Characterizing emerging canine H3 influenza viruses

AU - Martinez-Sobrido, Luis

AU - Blanco-Lobo, Pilar

AU - Rodriguez, Laura

AU - Fitzgerald, Theresa

AU - Zhang, Hanyuan

AU - Nguyen, Phuong

AU - Anderson, Christopher S.

AU - Holden-Wiltse, Jeanne

AU - Bandyopadhyay, Sanjukta

AU - Nogales, Aitor

AU - DeDiego, Marta L.

AU - Wasik, Brian R.

AU - Miller, Benjamin L.

AU - Henry, Carole

AU - Wilson, Patrick C.

AU - Sangster, Mark Y.

AU - Treanor, John J.

AU - Topham, David J.

AU - Byrd-Leotis, Lauren

AU - Steinhauer, David A.

AU - Cummings, Richard D.

AU - Luczo, Jasmina M.

AU - Tompkins, Stephen M.

AU - Sakamoto, Kaori

AU - Jones, Cheryl A.

AU - Steel, John

AU - Lowen, Anice C.

AU - Danzy, Shamika

AU - Tao, Hui

AU - Fink, Ashley L.

AU - Klein, Sabra L.

AU - Wohlgemuth, Nicholas

AU - Fenstermacher, Katherine J.

AU - el Najjar, Farah

AU - Pekosz, Andrew

AU - Sauer, Lauren

AU - Lewis, Mitra K.

AU - Shaw-Saliba, Kathryn

AU - Rothman, Richard E.

AU - Liu, Zhen Ying

AU - Chen, Kuan Fu

AU - Parrish, Colin R.

AU - Voorhees, Ian E.H.

AU - Kawaoka, Yoshihiro

AU - Neumann, Gabriele

AU - Chiba, Shiho

AU - Fan, Shufang

AU - Hatta, Masato

AU - Kong, Huihui

AU - Zhong, Gongxun

AU - Wang, Guojun

AU - Uccellini, Melissa B.

AU - García-Sastre, Adolfo

AU - Perez, Daniel R.

AU - Ferreri, Lucas M.

AU - Herfst, Sander

AU - Richard, Mathilde

AU - Fouchier, Ron

AU - Burke, David

AU - Pattinson, David

AU - Smith, Derek J.

AU - Meliopoulos, Victoria

AU - Freiden, Pamela

AU - Livingston, Brandi

AU - Sharp, Bridgett

AU - Cherry, Sean

AU - Dib, Juan Carlos

AU - Yang, Guohua

AU - Russell, Charles J.

AU - Barman, Subrata

AU - Webby, Richard J.

AU - Krauss, Scott

AU - Danner, Angela

AU - Woodard, Karlie

AU - Peiris, Malik

AU - Perera, R. A.P.M.

AU - Chan, M. C.W.

AU - Govorkova, Elena A.

AU - Marathe, Bindumadhav M.

AU - Pascua, Philippe N.Q.

AU - Smith, Gavin

AU - Li, Yao Tsun

AU - Thomas, Paul G.

AU - Schultz-Cherry, Stacey

N1 - Publisher Copyright: © 2020 Martinez-Sobrido et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2020/4

Y1 - 2020/4

N2 - The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.

AB - The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.

UR - http://www.scopus.com/inward/record.url?scp=85084104244&partnerID=8YFLogxK

U2 - 10.1371/journal.ppat.1008409

DO - 10.1371/journal.ppat.1008409

M3 - 文章

C2 - 32287326

AN - SCOPUS:85084104244

SN - 1553-7366

VL - 16

JO - PLoS Pathogens

JF - PLoS Pathogens

IS - 4

M1 - e1008409

ER -

Characterizing emerging canine H3 influenza viruses

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