Charge-monitoring laser-induced acoustic desorption mass spectrometry for cell and microparticle mass distribution measurement

Wen Ping Peng*, Huan Chang Lin, Hsin Hung Lin, Minglee Chu, Alice L. Yu, Huan Cheng Chang, Chung Hsuan Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

55 Scopus citations

Abstract

Mass exodus: A mass spectrometer for the rapid measurement of mass distributions of cells and microparticles is described. A discharge process is used to provide cells with thousands of charges so that direct charge measurement can be achieved. This device was used to measure microparticles with masses as high as 1015 Da and to distinguish cancer cells from normal cells. (Figure Presented).

Original languageEnglish
Pages (from-to)3865-3869
Number of pages5
JournalAngewandte Chemie - International Edition
Volume46
Issue number21
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Cells
  • Charge detection
  • Ion trap
  • Mass spectrometry
  • Microparticles

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