Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities

Ping Chung Kuo; Tsong Long Hwang; Ying Ting Lin; Yuh Chi Kuo; Yann Lii Leu

doi:10.1007/s12272-011-0503-7

Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities

Ping Chung Kuo, Tsong Long Hwang, Ying Ting Lin, Yuh Chi Kuo, Yann Lii Leu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

49 Scopus citations

Abstract

In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the literature. The structure of lobechine (1) was comprehensively established with the aid of 1D and 2D NMR spectroscopic analyses. In addition, selected isolates were screened for their inhibition of HSV-1 replication, superoxide anion generation, and elastase release. Among the tested compounds, scoparone (10) exhibited significant inhibition of superoxide anion generation with IC₅₀ of 6.14 ± 1.97 μM and lobechine (1) exhibited moderate inhibition of elastase release with IC₅₀ of 25.01 ± 6.95 μM, respectively.

Original language	English
Pages (from-to)	715-722
Number of pages	8
Journal	Archives of Pharmacal Research
Volume	34
Issue number	5
DOIs	https://doi.org/10.1007/s12272-011-0503-7
State	Published - 05 2011

Keywords

Elastase release
Lobechine
Lobelia chinensis
Superoxide anion generation

Access to Document

10.1007/s12272-011-0503-7

Cite this

@article{03a7aed6a65943e1a65a13522fd9a128,

title = "Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities",

abstract = "In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the literature. The structure of lobechine (1) was comprehensively established with the aid of 1D and 2D NMR spectroscopic analyses. In addition, selected isolates were screened for their inhibition of HSV-1 replication, superoxide anion generation, and elastase release. Among the tested compounds, scoparone (10) exhibited significant inhibition of superoxide anion generation with IC50 of 6.14 ± 1.97 μM and lobechine (1) exhibited moderate inhibition of elastase release with IC50 of 25.01 ± 6.95 μM, respectively.",

keywords = "Elastase release, Lobechine, Lobelia chinensis, Superoxide anion generation",

author = "Kuo, {Ping Chung} and Hwang, {Tsong Long} and Lin, {Ying Ting} and Kuo, {Yuh Chi} and Leu, {Yann Lii}",

year = "2011",

month = may,

doi = "10.1007/s12272-011-0503-7",

language = "英语",

volume = "34",

pages = "715--722",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "5",

}

TY - JOUR

T1 - Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities

AU - Kuo, Ping Chung

AU - Hwang, Tsong Long

AU - Lin, Ying Ting

AU - Kuo, Yuh Chi

AU - Leu, Yann Lii

PY - 2011/5

Y1 - 2011/5

N2 - In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the literature. The structure of lobechine (1) was comprehensively established with the aid of 1D and 2D NMR spectroscopic analyses. In addition, selected isolates were screened for their inhibition of HSV-1 replication, superoxide anion generation, and elastase release. Among the tested compounds, scoparone (10) exhibited significant inhibition of superoxide anion generation with IC50 of 6.14 ± 1.97 μM and lobechine (1) exhibited moderate inhibition of elastase release with IC50 of 25.01 ± 6.95 μM, respectively.

AB - In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the literature. The structure of lobechine (1) was comprehensively established with the aid of 1D and 2D NMR spectroscopic analyses. In addition, selected isolates were screened for their inhibition of HSV-1 replication, superoxide anion generation, and elastase release. Among the tested compounds, scoparone (10) exhibited significant inhibition of superoxide anion generation with IC50 of 6.14 ± 1.97 μM and lobechine (1) exhibited moderate inhibition of elastase release with IC50 of 25.01 ± 6.95 μM, respectively.

KW - Elastase release

KW - Lobechine

KW - Lobelia chinensis

KW - Superoxide anion generation

UR - http://www.scopus.com/inward/record.url?scp=79960239504&partnerID=8YFLogxK

U2 - 10.1007/s12272-011-0503-7

DO - 10.1007/s12272-011-0503-7

M3 - 文章

C2 - 21656355

AN - SCOPUS:79960239504

SN - 0253-6269

VL - 34

SP - 715

EP - 722

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 5

ER -

Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this