Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam; Po Hsun Chen; Hsin Yi Hung; Tsong Long Hwang; Chih Chao Chiang; Tran Dinh Thang; Ping Chung Kuo; Tian Shung Wu

doi:10.3390/molecules23102541

Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam, Po Hsun Chen, Hsin Yi Hung, Tsong Long Hwang, Chih Chao Chiang, Tran Dinh Thang, Ping Chung Kuo^*, Tian Shung Wu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

Original language	English
Article number	2541
Journal	Molecules
Volume	23
Issue number	10
DOIs	https://doi.org/10.3390/molecules23102541
State	Published - 05 10 2018

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Keywords

Elastase release
Lignan
Menispermaceae
Pyrrole alkaloid
Superoxide anion generation

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title = "Chemical constituents from the stems of tinospora sinensis and their bioactivity",

abstract = "Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.",

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AU - Lam, Sio Hong

AU - Chen, Po Hsun

AU - Hung, Hsin Yi

AU - Hwang, Tsong Long

AU - Chiang, Chih Chao

AU - Thang, Tran Dinh

AU - Kuo, Ping Chung

AU - Wu, Tian Shung

PY - 2018/10/5

Y1 - 2018/10/5

N2 - Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

AB - Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

KW - Elastase release

KW - Lignan

KW - Menispermaceae

KW - Pyrrole alkaloid

KW - Superoxide anion generation

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Chemical constituents from the stems of tinospora sinensis and their bioactivity

Abstract

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Keywords

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