Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Che Wei Lin; Tsong Long Hwang; Fu An Chen; Chia Hsin Huang; Hsin Yi Hung; Tian Shung Wu

doi:10.1021/acs.jnatprod.6b00118

Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Che Wei Lin, Tsong Long Hwang, Fu An Chen, Chia Hsin Huang, Hsin Yi Hung^*, Tian Shung Wu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

46 Scopus citations

Abstract

Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC₅₀ values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.

Original language	English
Pages (from-to)	1911-1921
Number of pages	11
Journal	Journal of Natural Products
Volume	79
Issue number	8
DOIs	https://doi.org/10.1021/acs.jnatprod.6b00118
State	Published - 26 08 2016

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Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.

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title = "Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity",

abstract = "Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.",

author = "Lin, {Che Wei} and Hwang, {Tsong Long} and Chen, {Fu An} and Huang, {Chia Hsin} and Hung, {Hsin Yi} and Wu, {Tian Shung}",

note = "Publisher Copyright: {\textcopyright} 2016 The American Chemical Society and American Society of Pharmacognosy.",

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doi = "10.1021/acs.jnatprod.6b00118",

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T1 - Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

AU - Lin, Che Wei

AU - Hwang, Tsong Long

AU - Chen, Fu An

AU - Huang, Chia Hsin

AU - Hung, Hsin Yi

AU - Wu, Tian Shung

PY - 2016/8/26

Y1 - 2016/8/26

N2 - Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.

AB - Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.

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Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

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