TY - JOUR
T1 - Chemistry and biology of Phellinus linteus
AU - Hsieh, Pei Wen
AU - Wu, Jin Bin
AU - Wu, Yang Chang
PY - 2013/9
Y1 - 2013/9
N2 - Phellinus linteus (PL) is a medicinal mushroom used to prevent or treat gastroenteric dysfunction, diarrhea, hemorrhage, allergy, diabetes, and cancer in East Asia, especially in China, Japan, and Korea. To demonstrate its pharmacological value and mechanism, and translate PL into western-accepted therapy, many researchers have investigated the effects of extracts from fruit-bodies (or mycelium) of PL by means of various invitro and invivo models. Subsequently, many small molecular weight pure components were isolated from extracts of PL to identify their pharmacological properties and mechanisms. These studies suggest PL and its bioactive compounds as promising candidates as anticancer, anti-inflammatory, and immunomodulating agents. This review comprehensively covers literature on these extracts, pure components, and potential therapeutic applications of PL from 1999 to June 2011. In particular, small molecular weight compounds that exhibit biological activity as well as pharmacological effects on PL's anticancer, anti-inflammatory, antidiabetic, neuro- and/or hepatic-protective, and immunomodulating activities are reviewed.
AB - Phellinus linteus (PL) is a medicinal mushroom used to prevent or treat gastroenteric dysfunction, diarrhea, hemorrhage, allergy, diabetes, and cancer in East Asia, especially in China, Japan, and Korea. To demonstrate its pharmacological value and mechanism, and translate PL into western-accepted therapy, many researchers have investigated the effects of extracts from fruit-bodies (or mycelium) of PL by means of various invitro and invivo models. Subsequently, many small molecular weight pure components were isolated from extracts of PL to identify their pharmacological properties and mechanisms. These studies suggest PL and its bioactive compounds as promising candidates as anticancer, anti-inflammatory, and immunomodulating agents. This review comprehensively covers literature on these extracts, pure components, and potential therapeutic applications of PL from 1999 to June 2011. In particular, small molecular weight compounds that exhibit biological activity as well as pharmacological effects on PL's anticancer, anti-inflammatory, antidiabetic, neuro- and/or hepatic-protective, and immunomodulating activities are reviewed.
KW - Anti-inflammatory
KW - Anticancer
KW - Bioactive compounds
KW - Fruiting body
KW - Phellinus linteus
UR - http://www.scopus.com/inward/record.url?scp=84881374212&partnerID=8YFLogxK
U2 - 10.1016/j.biomed.2013.01.002
DO - 10.1016/j.biomed.2013.01.002
M3 - 文献综述
AN - SCOPUS:84881374212
SN - 2211-8020
VL - 3
SP - 106
EP - 113
JO - BioMedicine (Netherlands)
JF - BioMedicine (Netherlands)
IS - 3
ER -
