Chiral Purification of S-Methyl-2-chloropropionate from Enantiomer Mixtures by Three-Phase Crystallization

Lie Ding Shiau*, Ming Hong Hsu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


Three-phase crystallization (TPC) was applied to purify S-methyl-2-chloropropionate (S-M2CP) from liquid enantiomer mixtures with various initial concentrations. TPC combines melt crystallization and vaporization to produce the desired crystalline solid along with the vapor from the liquid feed via a series of three-phase transformations. The three-phase states during TPC were calculated in terms of the thermodynamic properties of M2CP. Basically, the liquid mixture was gradually transformed to the S-M2CP crystalline solid and vapor mixture at reduced temperature and pressure during TPC. A model was proposed based on the material and energy balances to determine the variations of the masses of the remained liquid mixture, of the produced S-M2CP crystalline solid, and of the produced vapor mixture during the batch TPC operation. The results indicated that the experimental yield and purity for the final S-M2CP product obtained during TPC were consistent with those predicted by the model.

Original languageEnglish
Pages (from-to)2337-2344
Number of pages8
JournalChemical Engineering and Technology
Issue number11
StatePublished - 11 2023

Bibliographical note

Publisher Copyright:
© 2023 Wiley-VCH GmbH.


  • Crystallization
  • Enantiomer mixtures
  • Purification
  • Thermodynamics process
  • Vaporization


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