Chiral separation of the phenylglycinol enantiomers by stripping crystallization

Lie Ding Shiau*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations


Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in SC at low pressures during the cooling process. SC combines melt crystallization and vaporization to produce a crystalline product and mixture vapor from a mixture melt due to the three-phase transformation. Thermodynamic calculations were applied to determine the operating pressure for the three-phase transformation during the cooling process in the SC experiments. To consider the possible deviations between the calculated and the actual three-phase transformation conditions, the product purity and the recovery ratio of R-phenylglycinol were investigated within a range of operating pressures during the cooling process.

Original languageEnglish
Article number2901
Issue number11
StatePublished - 07 11 2018

Bibliographical note

Publisher Copyright:
© 2018 by the author.


  • Crystallization
  • Phenylglycinol
  • Purification
  • Vaporization


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