Chitosan: Applications in Drug Delivery System

Suresh Kumar, Ruby Dhiman, Carlos R. Prudencio, Antonio Charlys da Costa, Arpana Vibhuti, Elcio Leal, Chung Ming Chang, Vethakkani Samuel Raj, Ramendra Pati Pandey*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Chitin and chitosan have unique structures with significant functional groups carrying useful chemical capabilities. Chitin and chitosan are acknowledged as novel biomaterials with ad-vantageous biocompatibility and biodegradability. Chitosan is a polysaccharide that is made from chitin. There have been several attempts to employ this biopolymer in the biomedical area. This ma-terial's application in the production of artificial skin, drug targeting, and other areas is explored. The most prevalent strategies for recovering chitin from sea organisms are described and various pharmacological and biological uses are discussed. This review article targets drug delivery with the help of chitosan derived nanomaterial. The drug delivery system applications through nonmaterial have encountered a considerable role in the pharmaceutical, medical, biological, and other sectors in recent years. Nanomaterials have advanced applications as novel drug delivery systems in many fields, especially in industry, biology, and medicine. In the biomedical and pharmaceutical arena, the natural polymer-based nanoparticulate method has now been widely studied as particulate vehicles. By mixing alginate with other biopolymers, by immobilizing specific molecules such as sugar molecules and peptides by chemical or physical cross-linking, different properties and structures such as biodegradability, gelling properties, mechanical strength, and cell affinity can be obtained. Owing to their inherent ability to deliver both hydrophilic and hydrophobic drug molecules, increase stability, decrease toxicity, and enhance commonly formulated medications, these particles are now widely used in imaging and molecular diagnostics, cosmetics, household chemicals, sunscreens, radiation safety, and novel drug delivery.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalMini-Reviews in Medicinal Chemistry
Volume23
Issue number2
DOIs
StatePublished - 04 2023

Bibliographical note

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Keywords

  • Biopolymers
  • biological properties
  • nanomaterials
  • nanotoxicity
  • pharmaceutical nano-technology
  • physicochemical properties
  • toxicological effect
  • Chitin/chemistry
  • Biocompatible Materials/chemistry
  • Pharmaceutical Preparations
  • Chitosan/chemistry
  • Drug Delivery Systems

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