Chitosan containing PU/Poly(NIPAAm) thermosensitive membrane for wound dressing

Jen Ming Yang*, Shu Jyuan Yang, Hao Tzu Lin, Te Hsing Wu, Haw Jan Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

59 Scopus citations


Hydroxyl-terminated polybutadiene (HTPB) based polyurethane (PU) solution was prepared and then the PU solution was modified with N-isopropyl acrylamide by UV radiation without degassing to get thermo-sensitive membrane (PUNIPAAm). Then chitosan was impregnated onto the PUNIPAAm surface and treated by freeze-drying to get chitosan containing PUNIPAAm (PUNIPAAm-chi). Wettability on the various membranes was determined. The measurement of water vapor transmission rate on membranes and the antibacterial assessment were also evaluated. In order to evaluate the biocompatibility of these membranes, a cytotoxicity test and cell adhesion and proliferation assay were conducted in cell culture. The results showed that these thermo-sensitive PUNIPAAm membranes exhibited very low cytotoxicity and could support cell adhesion and growth. As having the antibacterial ability and the values of WVTR, permeance and permeability of the various PUNIPAAm-chi membranes are comparable to the commercial products, the PUNIPAAm-chi may be considered for wound dressing.

Original languageEnglish
Pages (from-to)150-156
Number of pages7
JournalMaterials Science and Engineering C
Issue number1
StatePublished - 10 01 2008


  • Antibacterial assessment
  • Cell culture
  • Poly(N-isopropyl acrylamide)
  • Polyurethane
  • Thermo-sensitivity
  • Wound dressing


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