Chronic granulomatous disease: A case report

Chih Hsing Hung, Yi Ming Hua, Ching Feng Huang, Wen Tsung Luo, Kuender D. Yang, Mong Ling Chu, Chih Chien Wang

Research output: Contribution to journalJournal Article peer-review

10 Scopus citations

Abstract

Chronic granulomatous disease is one form of the phagocyte function disorder. Unlike most patients with chronic granulomatous disease who develop signs and symptoms of chronic and recurrent pyogenic infections during the first 2 years of life, patients with mild forms of the disease may not present until the teenage years or even adulthood. Thus, the diagnosis in these mild-form patients is often delayed. This paper describes a patient with the mild form of chronic granulomatous disease. A 7-year-old boy was admitted to our ward with intermittent high fever and a left neck mass present for about 1 week. He had a history of persistent infection in the bilateral lower face lasting for about 1 year during his fourth year of life. Family history was unremarkable except that the patient's elder sister had a history of persistent oral mucosal wound infection for about 1 year during the fifth year of life. On physical examination, there were scars over the patient's bilateral lower face. Bacterial culture of pus drained from the neck mass revealed Burkholderia cepacia, a rare species in patients without immunodeficiency. A series of antibiotics, including oxacillin, clindamycin, and piperacillin, was given, and two incision operations for drainage and debridement were performed. The neck mass resolved completely about 1.5 months later. This history indicated that the patient might have chronic granulomatous disease. A definite absence of superoxide activity in the patient's granulocytes detected by chemiluminescence and nitroblue tetrazolium dye test confirmed this diagnosis.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalJournal of the Formosan Medical Association
Volume100
Issue number4
StatePublished - 04 2001
Externally publishedYes

Keywords

  • Burkholderia cepacia
  • Chronic granulomatous disease
  • Superoxide

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