Chronic inflammation and hepatocellular carcinoma.

Malcolm R. Alison; Linda J. Nicholson; Wey Ran Lin

doi:10.1007/978-3-642-03503-6_8

Chronic inflammation and hepatocellular carcinoma.

Malcolm R. Alison^*
, Linda J. Nicholson
, Wey Ran Lin

^*Corresponding author for this work

School of Medicine

Queen Mary University of London

Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) invariably develops within a setting of chronic inflammation caused by either hepatotropic viruses, toxins, metabolic liver disease or autoimmunity. Mechanisms that link these two processes are not completely understood, but transcription factors of the NF-κB family and signal transducer and activator of transcription 3 (STAT3), cytokines such as IL-6 and IL-1α and ligands of the epidermal growth factor receptor (EGFR) family are clearly pivotal players. HCC may have its origins in either hepatocytes or hepatic progenitor cells (HPCs), and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.

Original language	English
Pages (from-to)	135-148
Number of pages	14
Journal	Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
Volume	185
DOIs	https://doi.org/10.1007/978-3-642-03503-6_8
State	Published - 2011

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/978-3-642-03503-6_8

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title = "Chronic inflammation and hepatocellular carcinoma.",

abstract = "Hepatocellular carcinoma (HCC) invariably develops within a setting of chronic inflammation caused by either hepatotropic viruses, toxins, metabolic liver disease or autoimmunity. Mechanisms that link these two processes are not completely understood, but transcription factors of the NF-κB family and signal transducer and activator of transcription 3 (STAT3), cytokines such as IL-6 and IL-1α and ligands of the epidermal growth factor receptor (EGFR) family are clearly pivotal players. HCC may have its origins in either hepatocytes or hepatic progenitor cells (HPCs), and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.",

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T1 - Chronic inflammation and hepatocellular carcinoma.

AU - Alison, Malcolm R.

AU - Nicholson, Linda J.

AU - Lin, Wey Ran

PY - 2011

Y1 - 2011

N2 - Hepatocellular carcinoma (HCC) invariably develops within a setting of chronic inflammation caused by either hepatotropic viruses, toxins, metabolic liver disease or autoimmunity. Mechanisms that link these two processes are not completely understood, but transcription factors of the NF-κB family and signal transducer and activator of transcription 3 (STAT3), cytokines such as IL-6 and IL-1α and ligands of the epidermal growth factor receptor (EGFR) family are clearly pivotal players. HCC may have its origins in either hepatocytes or hepatic progenitor cells (HPCs), and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.

AB - Hepatocellular carcinoma (HCC) invariably develops within a setting of chronic inflammation caused by either hepatotropic viruses, toxins, metabolic liver disease or autoimmunity. Mechanisms that link these two processes are not completely understood, but transcription factors of the NF-κB family and signal transducer and activator of transcription 3 (STAT3), cytokines such as IL-6 and IL-1α and ligands of the epidermal growth factor receptor (EGFR) family are clearly pivotal players. HCC may have its origins in either hepatocytes or hepatic progenitor cells (HPCs), and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.

UR - https://www.scopus.com/pages/publications/84856394989

U2 - 10.1007/978-3-642-03503-6_8

DO - 10.1007/978-3-642-03503-6_8

M3 - 文献综述

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AN - SCOPUS:84856394989

SN - 0080-0015

VL - 185

SP - 135

EP - 148

JO - Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer

JF - Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer

ER -

Chronic inflammation and hepatocellular carcinoma.

Abstract

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