Chronic Kidney Disease: Interaction of Adiponectin Gene Polymorphisms and Diabetes

Hsi Hsien Chen, Ya Li Huang, Mei Chieh Chen, Chih Yin Wu, Ying Chin Lin, Horng Sheng Shiue, Sheng Lun Hsu, Yu Mei Hsueh*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations

Abstract

Adiponectin is an adipokine multipeptide hormone with insulin-sensitizing; anti-atherosclerotic; and anti-inflammatory properties. Chronic kidney disease (CKD) may be associated with low adiponectin. The adiponectin gene ADIPOQ is thought to be the only major gene responsible for plasma adiponectin levels; which are associated with diabetes and diabetic nephropathy. The purpose of this study was to investigate the association between ADIPOQ polymorphism and CKD. In addition; the combined effects of ADIPOQ polymorphism and diabetes and levels of total urinary arsenic and blood cadmium on CKD were also explored. This study included 215 CKD patients and 423 age–sex matched controls. The ADIPOQ polymorphisms were determined using the Agena Bioscience Mass ARRAY System. The levels of blood cadmium and urinary arsenic species were measured. The ADIPOQ rs182052 GA/AA genotype had a marginally lower odds ratio (OR) for CKD than the GG genotype. The OR (95% confidence interval; CI) was 16.33 (5.72–46.66) of CKD in subjects carrying the ADIPOQ rs182052 GG genotype and diabetes compared to non-diabetes subjects carrying the ADIPOQ rs182052 GA/AA genotype; the interaction term had p = 0.015; and the synergy index was 6.64 (1.81–24.36) after multivariate adjustment. A significant interaction of diabetes and ADIPOQ rs1501299 risk genotype increased the OR of CKD after multivariate adjustment with a synergy index of 0.31 (0.11–0.86) and a multiplicative interaction with p = 0.001. These results suggest that ADIPOQ rs182052 and rs1501299 risk genotypes may significantly modify the association between diabetes and CKD but not the association between total urinary arsenic and blood cadmium and CKD.

Original languageEnglish
Article number8128
JournalInternational Journal of Molecular Sciences
Volume24
Issue number9
DOIs
StatePublished - 01 05 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • adiponectin
  • arsenic
  • cadmium
  • chronic kidney disease
  • diabetes
  • polymorphisms
  • Cadmium
  • Genetic Predisposition to Disease
  • Adiponectin/genetics
  • Arsenic
  • Diabetes Mellitus/genetics
  • Humans
  • Diabetic Nephropathies/genetics
  • Genotype
  • Case-Control Studies
  • Polymorphism, Single Nucleotide

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