CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons

Ching Jung Lee; Wai In Chan; Martin Cheung; Yi Chuan Cheng; Vanessa J. Appleby; Alex T. Orme; Paul J. Scotting

doi:10.1016/S0169-328X(02)00439-4

CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons

Ching Jung Lee
, Wai In Chan
, Martin Cheung
, Yi Chuan Cheng
, Vanessa J. Appleby
, Alex T. Orme
, Paul J. Scotting

University of Nottingham

Research output: Contribution to journal › Journal Article › peer-review

56 Scopus citations

Abstract

We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes. These are orthologs of the Drosophila gene capicua, and represent a new subfamily of the HMG-box superfamily. Expression of the Cic gene is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS. This gene is therefore implicated in CNS development, in particular in granule cell development.

Original language	English
Pages (from-to)	151-156
Number of pages	6
Journal	Molecular Brain Research
Volume	106
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(02)00439-4
State	Published - 15 10 2002
Externally published	Yes

Keywords

Cerebellum
Granule cell
HMG-box

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10.1016/S0169-328X(02)00439-4

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title = "CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons",

abstract = "We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes. These are orthologs of the Drosophila gene capicua, and represent a new subfamily of the HMG-box superfamily. Expression of the Cic gene is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS. This gene is therefore implicated in CNS development, in particular in granule cell development.",

keywords = "Cerebellum, Granule cell, HMG-box",

author = "Lee, \{Ching Jung\} and Chan, \{Wai In\} and Martin Cheung and Cheng, \{Yi Chuan\} and Appleby, \{Vanessa J.\} and Orme, \{Alex T.\} and Scotting, \{Paul J.\}",

year = "2002",

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doi = "10.1016/S0169-328X(02)00439-4",

language = "英语",

volume = "106",

pages = "151--156",

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TY - JOUR

T1 - CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons

AU - Lee, Ching Jung

AU - Chan, Wai In

AU - Cheung, Martin

AU - Cheng, Yi Chuan

AU - Appleby, Vanessa J.

AU - Orme, Alex T.

AU - Scotting, Paul J.

PY - 2002/10/15

Y1 - 2002/10/15

N2 - We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes. These are orthologs of the Drosophila gene capicua, and represent a new subfamily of the HMG-box superfamily. Expression of the Cic gene is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS. This gene is therefore implicated in CNS development, in particular in granule cell development.

AB - We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes. These are orthologs of the Drosophila gene capicua, and represent a new subfamily of the HMG-box superfamily. Expression of the Cic gene is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS. This gene is therefore implicated in CNS development, in particular in granule cell development.

KW - Cerebellum

KW - Granule cell

KW - HMG-box

UR - https://www.scopus.com/pages/publications/0037109167

U2 - 10.1016/S0169-328X(02)00439-4

DO - 10.1016/S0169-328X(02)00439-4

M3 - 文章

C2 - 12393275

AN - SCOPUS:0037109167

SN - 0169-328X

VL - 106

SP - 151

EP - 156

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1-2

ER -

CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons

Abstract

Keywords

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