Cingulate white matter mediates the effects of fecal Ruminococcus on neuropsychiatric symptoms in patients with amyloid-positive amnestic mild cognitive impairment

Chun Che Hung, Yi Ping Chao, Yejin Lee, Chi Wei Huang, Shu Hua Huang, Chiung Chih Chang*, Chia Hsiung Cheng*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

Background: Microbiota-gut-brain axis interacts with one another to regulate brain functions. However, whether the impacts of gut dysbiosis on limbic white matter (WM) tracts contribute to the neuropsychiatric symptoms (NPS) in patients with amyloid-positive amnestic mild cognitive impairment (aMCI+), have not been explored yet. This study aimed to investigate the mediation effects of limbic WM integrity on the association between gut microbiota and NPS in patients with aMCI+. Methods: Twenty patients with aMCI + and 20 healthy controls (HCs) were enrolled. All subjects underwent neuropsychological assessments and their microbial compositions were characterized using 16S rRNA Miseq sequencing technique. Amyloid deposition inspected by positron emission tomography imaging and limbic WM tracts (i.e., fornix, cingulum, and uncinate fasciculus) detected by diffusion tensor imaging were additionally measured in patients with aMCI+. We employed a regression-based mediation analysis using Hayes’s PROCESS macro in this study. Results: The relative abundance of genera Ruminococcus and Lactococcus was significantly decreased in patients with aMCI + versus HCs. The relative abundance of Ruminococcus was negatively correlated with affective symptom cluster in the aMCI + group. Notably, this association was mediated by WM integrity of the left cingulate gyrus. Conclusions: Our findings suggest Ruminococcus as a potential target for the management of affective impairments in patients with aMCI+.

Original languageEnglish
Article number720
JournalBMC Geriatrics
Volume23
Issue number1
DOIs
StatePublished - 12 2023

Bibliographical note

Publisher Copyright:
© 2023, The Author(s).

Keywords

  • Amnestic mild cognitive impairment
  • Diffusion tensor imaging
  • Gut microbiota
  • Limbic system
  • Neuropsychiatric symptoms
  • Ruminococcus

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