Circulating microRNA-196a is an early gastric cancer biomarker

Tsung Hsing Chen, Chieh Lee, Cheng Tang Chiu, Yin Yi Chu, Hao Tsai Cheng, Jun Te Hsu, Yung Kuan Tsou, Ren Chin Wu, Tse Ching Chen, Nien Chen Chang, Ta Sen Yeh, Kwang Huei Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

19 Scopus citations

Abstract

MicroRNA-196a (miRNA-196a) is associated with the development of gastric cancer and metastasis. Intestinal metaplasia and low- or high-grade dysplasia are considered to be precursors of intestinal type gastric cancer. Accordingly, we investigated the expression of plasma miRNA-196a as an early detection biomarker in precancerous gastric lesions and early cancer (pT1a/b), which is otherwise treated with endoscopic submucosal dissection. Our data showed that levels of circulating (plasma) miRNA-196a were higher in patients with precancerous lesions/early gastric adenocarcinoma than in healthy controls. The area under the receiver operating characteristic curve (AUC) for healthy controls vs. intestinal metaplasia was 0.9736; healthy controls vs. low-grade/high-grade dysplasia 0.9495; and healthy controls vs. early gastric cancer 0.9318. These results indicate that circulating miRNA-196a is a novel biomarker for detection of early gastric cancer and its precursor.

Original languageEnglish
Pages (from-to)10317-10323
Number of pages7
JournalOncotarget
Volume9
Issue number12
DOIs
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© Chen et al.

Keywords

  • Dysplasia
  • Early gastric cancer
  • Intestinal metaplasia
  • MicroRNA-196a
  • Precancerous gastric lesions

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