Abstract
MicroRNA-196a (miRNA-196a) is associated with the development of gastric cancer and metastasis. Intestinal metaplasia and low- or high-grade dysplasia are considered to be precursors of intestinal type gastric cancer. Accordingly, we investigated the expression of plasma miRNA-196a as an early detection biomarker in precancerous gastric lesions and early cancer (pT1a/b), which is otherwise treated with endoscopic submucosal dissection. Our data showed that levels of circulating (plasma) miRNA-196a were higher in patients with precancerous lesions/early gastric adenocarcinoma than in healthy controls. The area under the receiver operating characteristic curve (AUC) for healthy controls vs. intestinal metaplasia was 0.9736; healthy controls vs. low-grade/high-grade dysplasia 0.9495; and healthy controls vs. early gastric cancer 0.9318. These results indicate that circulating miRNA-196a is a novel biomarker for detection of early gastric cancer and its precursor.
Original language | English |
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Pages (from-to) | 10317-10323 |
Number of pages | 7 |
Journal | Oncotarget |
Volume | 9 |
Issue number | 12 |
DOIs | |
State | Published - 2018 |
Bibliographical note
Publisher Copyright:© Chen et al.
Keywords
- Dysplasia
- Early gastric cancer
- Intestinal metaplasia
- MicroRNA-196a
- Precancerous gastric lesions